| Gene Symbol |
SMARCD3
|
| Entrez Gene |
6604
|
| Alt Symbol |
BAF60C, CRACD3, Rsc6p
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
|
| Other Description |
60 kDa BRG-1/Brm-associated factor subunit C|BRG1-associated factor 60C|SWI/SNF complex 60 kDa subunit C|SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3|Swp73-like protein|chromatin remodeling complex BAF60C subunit|mammalian chromatin remodeling complex BRG1-associated factor 60C
|
| Swissprots |
Q6STE5 Q92926 Q2YD86 Q9BUH1 Q75MR8 D3DX10 Q75MJ2
|
| Accessions |
AAS00380 AAS02031 EAL24510 EAW54005 EAW54006 EAW54007 EAW54008 EAW54009 Q6STE5 AK127595 BAG54531 AK297876 BAH12684 AK309500 AK316173 BAH14544 AY450430 AAR88510 AY450431 AAR88511 BC002628 AAH02628 BC110350 AAI10351 BI598614 BX648385 U66619 AAC50697 XM_011516521 XP_011514823 XR_927517 XR_927518 XR_927519 NM_001003801 NP_001003801 NM_001003802 NP_001003802 NM_003078 NP_003069
|
| Function |
Plays a role in ATP dependent nucleosome remodeling by SMARCA4 containing complexes. Stimulates nuclear receptor mediated transcription. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron- specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post- mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:14701856}.
|
| Tissue Specificity |
Isoform 2 and isoform 1 are expressed in brain, heart, kidney, placenta, prostate, salivary gland, spleen, testis, thyroid, trachea and uterus. Isoform 1 is also expressed in skeletal muscle and adipose tissue.
|