| Gene Symbol |
ORC4
|
| Entrez Gene |
5000
|
| Alt Symbol |
ORC4L, ORC4P
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
origin recognition complex, subunit 4
|
| Other Description |
origin recognition complex subunit 4|origin recognition complex, subunit 4 homolog
|
| Swissprots |
O43929 B7Z3D0 Q96C42 B7Z5F1 D3DP86 F5H069
|
| Accessions |
AAS94326 AAX93051 AAY24232 EAX11555 EAX11556 EAX11557 EAX11558 EAX11559 EAX11560 O43929 AF022108 AAC01957 AF047598 AAC80282 AF132596 AAD22110 AK055257 AK128860 AK225092 AK291989 BAF84678 AK294878 BAH11910 AK295721 BAH12166 AK298862 BAH12887 AK299749 BAH13118 AV708885 BC005388 BC014847 AAH14847 BC016177 AAH16177 BI603609 BM468640 BM926755 BP277082 BP345092 BQ716497 BX423253 CD242597 DA120022 DA227202 DB558580 DC302315 DC317404 DC329505 DC365436 DC365653 DC399282 DC399552 EU446991 ABZ92520 XM_006712556 XP_006712619 XM_011511255 XP_011509557 NM_001190879 NP_001177808 NM_001190881 NP_001177810 NM_001190882 NP_001177811 NM_002552 NP_002543 NM_181741 NP_859525 NM_181742 NP_859526
|
| Function |
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre- replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3. {ECO:0000269|PubMed:22427655}.
|
| Subcellular Location |
Nucleus.
|
| Top Pathways |
Cell cycle
|