Gene Symbol | MED14 |
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Entrez Gene | 9282 |
Alt Symbol | CRSP150, CRSP2, CSRP, CXorf4, DRIP150, EXLM1, RGR1, TRAP170 |
Species | Human |
Gene Type | protein-coding |
Description | mediator complex subunit 14 |
Other Description | ARC150|CRSP complex subunit 2|RGR1 homolog|activator-recruited cofactor 150 kDa component|cofactor required for Sp1 transcriptional activation, subunit 2 (150kD)|hRGR1|human homolog of yeast RGR1|mediator of RNA polymerase II transcription subunit 14|thyroid hormone receptor-associated protein complex 170 kDa component|thyroid hormone receptor-associated protein complex component TRAP170|transcriptional co-activator CRSP150|vitamin D receptor-interacting protein complex component DRIP150|vitamin D3 receptor-interacting protein complex 150 kDa component |
Swissprots | Q9UNB3 Q4KMR7 O60244 |
Accessions | BAA28627 EAW59419 EAW59420 O60244 AB006651 BAA28626 AF070563 AF104256 AAD12725 AF135802 AAD24360 AF304448 AAG22547 AJ012077 AK023368 AK293070 BAF85759 AK308871 BC098377 AAH98377 BC132672 AAI32673 BC132674 AAI32675 BC144231 HG518165 CDI06888 XM_005272701 XP_005272758 XM_011544000 XP_011542302 NM_004229 NP_004220 |
Function | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:15340088, ECO:0000269|PubMed:15625066, ECO:0000269|PubMed:16595664}. |
Subcellular Location | Nucleus {ECO:0000305}. |
Tissue Specificity | Ubiquitous. |
CRSP150 (M-19) - sc-9419 from Santa Cruz Biotechnology
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CRSP150 (H-300) - sc-366073 from Santa Cruz Biotechnology
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CRSP150 (C-17) - sc-9420 from Santa Cruz Biotechnology
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CRSP150 (2214C1a) - sc-81236 from Santa Cruz Biotechnology
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Anti-CRSP2 / MED14 antibody - ab72141 from Abcam
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Anti-CRSP2 / MED14 antibody - ab196624 from Abcam
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Anti-CRSP2 / MED14 antibody - ab170605 from Abcam
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Anti-CRSP2 / MED14 antibody [2214C1a] - ab51349 from Abcam
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Anti-CRSP2 / MED14 antibody - C-terminal - ab135052 from Abcam
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Anti-MED14 Antibody - LS-C79468 from LifeSpan Bioscience
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Anti-MED14 Antibody (clone 2214C1a) - LS-C184377 from LifeSpan Bioscience
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Anti-MED14 Antibody (aa701-750) - LS-C118689 from LifeSpan Bioscience
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Anti-MED14 Antibody (aa585-615, AP) - LS-C223264 from LifeSpan Bioscience
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Anti-MED14 Antibody (aa585-615, APC) - LS-C223265 from LifeSpan Bioscience
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Anti-MED14 Antibody (aa585-615, Biotin) - LS-C223266 from LifeSpan Bioscience
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Anti-MED14 Antibody (aa585-615, FITC) - LS-C223267 from LifeSpan Bioscience
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Anti-MED14 Antibody - LS-C158121 from LifeSpan Bioscience
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Anti-MED14 Antibody (aa585-615, Azide-free, HRP) - LS-C223268 from LifeSpan Bioscience
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Anti-MED14 Antibody (aa585-615, PE) - LS-C223269 from LifeSpan Bioscience
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Anti-MED14 Antibody (aa575-624) - LS-C116775 from LifeSpan Bioscience
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Anti-MED14 Antibody (aa1-50) - LS-C287874 from LifeSpan Bioscience
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Anti-MED14 Antibody (aa585-615) - LS-C322934 from LifeSpan Bioscience
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Anti-MED14 Antibody (aa586-615) - LS-C164115 from LifeSpan Bioscience
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Anti-MED14 Antibody (clone 2214C1a) - LS-C342427 from LifeSpan Bioscience
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MED14 Antibody - NBP1-67781 from Novus Biologicals
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