Gene Symbol | MED14 |
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Entrez Gene | 9282 |
Alt Symbol | CRSP150, CRSP2, CSRP, CXorf4, DRIP150, EXLM1, RGR1, TRAP170 |
Species | Human |
Gene Type | protein-coding |
Description | mediator complex subunit 14 |
Other Description | ARC150|CRSP complex subunit 2|RGR1 homolog|activator-recruited cofactor 150 kDa component|cofactor required for Sp1 transcriptional activation, subunit 2 (150kD)|hRGR1|human homolog of yeast RGR1|mediator of RNA polymerase II transcription subunit 14|thyroid hormone receptor-associated protein complex 170 kDa component|thyroid hormone receptor-associated protein complex component TRAP170|transcriptional co-activator CRSP150|vitamin D receptor-interacting protein complex component DRIP150|vitamin D3 receptor-interacting protein complex 150 kDa component |
Swissprots | Q9UNB3 Q4KMR7 O60244 |
Accessions | BAA28627 EAW59419 EAW59420 O60244 AB006651 BAA28626 AF070563 AF104256 AAD12725 AF135802 AAD24360 AF304448 AAG22547 AJ012077 AK023368 AK293070 BAF85759 AK308871 BC098377 AAH98377 BC132672 AAI32673 BC132674 AAI32675 BC144231 HG518165 CDI06888 XM_005272701 XP_005272758 XM_011544000 XP_011542302 NM_004229 NP_004220 |
Function | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:15340088, ECO:0000269|PubMed:15625066, ECO:0000269|PubMed:16595664}. |
Subcellular Location | Nucleus {ECO:0000305}. |
Tissue Specificity | Ubiquitous. |
CRSP150 CRISPR/Cas9 KO Plasmid (h) - sc-406011 from Santa Cruz Biotechnology
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CRSP150 HDR Plasmid (h) - sc-406011-HDR from Santa Cruz Biotechnology
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CRSP150 Double Nickase Plasmid (h) - sc-406011-NIC from Santa Cruz Biotechnology
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CRSP150 Double Nickase Plasmid (h2) - sc-406011-NIC-2 from Santa Cruz Biotechnology
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CRSP150 CRISPR Activation Plasmid (h) - sc-406011-ACT from Santa Cruz Biotechnology
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CRSP150 CRISPR Activation Plasmid (h2) - sc-406011-ACT-2 from Santa Cruz Biotechnology
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CRSP150 Lentiviral Activation Particles (h) - sc-406011-LAC from Santa Cruz Biotechnology
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CRSP150 Lentiviral Activation Particles (h2) - sc-406011-LAC-2 from Santa Cruz Biotechnology
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CRSP150 siRNA (h) - sc-38579 from Santa Cruz Biotechnology
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CRSP150 shRNA Plasmid (h) - sc-38579-SH from Santa Cruz Biotechnology
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CRSP150 shRNA (h) Lentiviral Particles - sc-38579-V from Santa Cruz Biotechnology
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MED14 RNAi - H00009282-R01 from Novus Biologicals
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MISSION® esiRNA - EHU019921 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN13163 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13163 from Sigma-Aldrich
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MED14 siRNA (Human) - CRH6145 from Cohesion Biosciences
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shRNA set against Human MED14 (NM_004229.3) - SHH339907 from Creative biogene
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shRNA set against Human CRSP2(NM_004229.3) - SHH000721 from Creative biogene
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MED14 shRNA Plasmid (Human) - CHH6145 from Cohesion Biosciences
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MED14 miRNA 3'UTR clone - MiUTR1H-02438 from Creative biogene
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