| Gene Symbol |
MED14
|
| Entrez Gene |
9282
|
| Alt Symbol |
CRSP150, CRSP2, CSRP, CXorf4, DRIP150, EXLM1, RGR1, TRAP170
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mediator complex subunit 14
|
| Other Description |
ARC150|CRSP complex subunit 2|RGR1 homolog|activator-recruited cofactor 150 kDa component|cofactor required for Sp1 transcriptional activation, subunit 2 (150kD)|hRGR1|human homolog of yeast RGR1|mediator of RNA polymerase II transcription subunit 14|thyroid hormone receptor-associated protein complex 170 kDa component|thyroid hormone receptor-associated protein complex component TRAP170|transcriptional co-activator CRSP150|vitamin D receptor-interacting protein complex component DRIP150|vitamin D3 receptor-interacting protein complex 150 kDa component
|
| Swissprots |
Q9UNB3 Q4KMR7 O60244
|
| Accessions |
BAA28627 EAW59419 EAW59420 O60244 AB006651 BAA28626 AF070563 AF104256 AAD12725 AF135802 AAD24360 AF304448 AAG22547 AJ012077 AK023368 AK293070 BAF85759 AK308871 BC098377 AAH98377 BC132672 AAI32673 BC132674 AAI32675 BC144231 HG518165 CDI06888 XM_005272701 XP_005272758 XM_011544000 XP_011542302 NM_004229 NP_004220
|
| Function |
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. {ECO:0000269|PubMed:15340088, ECO:0000269|PubMed:15625066, ECO:0000269|PubMed:16595664}.
|
| Subcellular Location |
Nucleus {ECO:0000305}.
|
| Tissue Specificity |
Ubiquitous.
|
