| Gene Symbol |
DOCK4
|
| Entrez Gene |
9732
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
dedicator of cytokinesis 4
|
| Other Description |
dedicator of cytokinesis protein 4
|
| Swissprots |
O14584 Q8N1I0 Q8NB45 O94824
|
| Accessions |
AAB83946 AAS07431 EAL24377 EAW83451 EAW83452 EAW83453 EAW83454 EAW83455 EAW83456 Q8N1I0 AB018259 BAA34436 AF085922 AK055497 AK091557 BAC03696 AK098050 BAC05221 AK294722 BAH11861 AK294820 BAH11895 AK309605 AY233380 AAO73565 BC117688 AAI17689 BC117689 AAI17690 BC117694 AAI17695 BM126591 BM545903 DA646980 XM_006716188 XP_006716251 XM_006716189 XP_006716252 XM_011516716 XP_011515018 XM_011516717 XP_011515019 NM_014705 NP_055520
|
| Function |
Involved in regulation of adherens junction between cells. Plays a role in cell migration. Functions as a guanine nucleotide exchange factor (GEF), which activates Rap1 small GTPase by exchanging bound GDP for free GTP. {ECO:0000269|PubMed:12628187, ECO:0000269|PubMed:20679435}.
|
| Subcellular Location |
Endomembrane system; Peripheral membrane protein. Cytoplasm, cytosol.
|
| Tissue Specificity |
Widely expressed at low level. Highly expressed in skeletal muscle, prostate and ovary. {ECO:0000269|PubMed:12628187}.
|
| Top Pathways |
Rap1 signaling pathway
|