HERPUD1
| Gene Symbol | HERPUD1 |
|---|---|
| Entrez Gene | 9709 |
| Alt Symbol | HERP, Mif1, SUP |
| Species | Human |
| Gene Type | protein-coding |
| Description | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 |
| Other Description | MMS-inducible|homocysteine-inducible endoplasmic reticulum stress-inducible ubiquitin-like domain member 1 protein|homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein|methyl methanesulfonate (MMF)-inducible fragment protein 1 |
| Swissprots | Q96D92 O60644 Q15011 E9PGD1 Q6IAN8 |
| Accessions | BAB19010 EAW82892 EAW82893 EAW82894 Q15011 AB034989 BAB07891 AF055001 AAC09355 AF055003 AAC09357 AF217990 AAG17233 AK223233 BAD96953 AK291565 BAF84254 AK292088 BAF84777 AK302167 BAG63534 AK304800 BAG65550 BC000086 AAH00086 BC008320 AAH08320 BC009739 AAH09739 BC032673 AAH32673 BG685245 BI520043 CD358537 CR457116 CAG33397 D14695 BAA03521 DA581153 DQ837586 ABI18163 DQ891867 ABM82793 EU176642 ABW03443 XM_006721352 XP_006721415 NM_001010989 NP_001010989 NM_001272103 NP_001259032 NM_014685 NP_055500 NM_001010990 |
| Function | Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Could enhance presenilin-mediated beta-amyloid protein 40 generation. {ECO:0000269|PubMed:16289116}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:10922362}; Multi-pass membrane protein {ECO:0000269|PubMed:10922362}. |
| Tissue Specificity | Widely expressed; in the brain, expression seems to be restricted to neurons and vascular smooth muscle cells. Present in activated microglia in senile plaques in the brain of patients with Alzheimer disease. |
| Top Pathways | Protein processing in endoplasmic reticulum |
HERP CRISPR/Cas9 KO Plasmid (h) - sc-402787 from Santa Cruz Biotechnology
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HERP HDR Plasmid (h) - sc-402787-HDR from Santa Cruz Biotechnology
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HERP Double Nickase Plasmid (h) - sc-402787-NIC from Santa Cruz Biotechnology
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HERP Double Nickase Plasmid (h2) - sc-402787-NIC-2 from Santa Cruz Biotechnology
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HERP CRISPR Activation Plasmid (h) - sc-402787-ACT from Santa Cruz Biotechnology
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HERP CRISPR Activation Plasmid (h2) - sc-402787-ACT-2 from Santa Cruz Biotechnology
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HERP Lentiviral Activation Particles (h) - sc-402787-LAC from Santa Cruz Biotechnology
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HERP Lentiviral Activation Particles (h2) - sc-402787-LAC-2 from Santa Cruz Biotechnology
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HERP siRNA (h) - sc-75245 from Santa Cruz Biotechnology
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HERP shRNA Plasmid (h) - sc-75245-SH from Santa Cruz Biotechnology
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HERP shRNA (h) Lentiviral Particles - sc-75245-V from Santa Cruz Biotechnology
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HERPUD1 RNAi - H00009709-R01 from Novus Biologicals
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HERPUD1 RNAi - H00009709-R02 from Novus Biologicals
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HERPUD1 RNAi - H00009709-R03 from Novus Biologicals
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MISSION® esiRNA - EHU073141 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9988 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9988 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04474 from Sigma-Aldrich
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HERPUD1 siRNA (Human) - CRH6479 from Cohesion Biosciences
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HERPUD1 - MBS828646 from MyBioSource
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shRNA set against Human HERPUD1 (NM_014685.2) - SHH311653 from Creative biogene
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shRNA set against Human HERPUD1(NM_001010990.1) - SHH118649 from Creative biogene
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shRNA set against Human HERPUD1(NM_014685.2) - SHH118685 from Creative biogene
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shRNA set against Human HERPUD1(NM_001010989.1) - SHH118703 from Creative biogene
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Human HERPUD1 siRNA - orb266981 from Biorbyt
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