| Gene Symbol |
MAPK6
|
| Entrez Gene |
5597
|
| Alt Symbol |
ERK3, HsT17250, PRKM6, p97MAPK
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mitogen-activated protein kinase 6
|
| Other Description |
ERK-3|MAP kinase 6|MAP kinase isoform p97|MAPK 6|extracellular signal-regulated kinase 3|extracellular signal-regulated kinase, p97|p97-MAPK|protein kinase, mitogen-activated 5|protein kinase, mitogen-activated 6
|
| Swissprots |
Q16659 B5BU65 Q8IYN8 Q68DH4 B2R945
|
| Accessions |
EAW77434 Q16659 AB451301 BAG70115 AF420474 AAL17605 AK313633 BAG36392 BC035492 AAH35492 CR749401 CAH18246 DA109756 DQ891618 ABM82544 DQ894810 ABM85736 L77964 AAA98769 X80692 CAA56709 XM_005254536 XP_005254593 XM_005254537 XP_005254594 XM_005254538 XP_005254595 XM_005254539 XP_005254596 XM_011521782 XP_011520084 NM_002748 NP_002739
|
| Function |
Atypical MAPK protein. Phosphorylates microtubule- associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Translocates to the cytoplasm following interaction with MAPKAPK5. {ECO:0000250}.
|
| Tissue Specificity |
Highest expression in the skeletal muscle, followed by the brain. Also found in heart, placenta, lung, liver, pancreas, kidney and skin fibroblasts.
|
