MAPK6

Gene Symbol	MAPK6
Entrez Gene	5597
Alt Symbol	ERK3, HsT17250, PRKM6, p97MAPK
Species	Human
Gene Type	protein-coding
Description	mitogen-activated protein kinase 6
Other Description	ERK-3|MAP kinase 6|MAP kinase isoform p97|MAPK 6|extracellular signal-regulated kinase 3|extracellular signal-regulated kinase, p97|p97-MAPK|protein kinase, mitogen-activated 5|protein kinase, mitogen-activated 6
Swissprots	Q16659 B5BU65 Q8IYN8 Q68DH4 B2R945
Accessions	EAW77434 Q16659 AB451301 BAG70115 AF420474 AAL17605 AK313633 BAG36392 BC035492 AAH35492 CR749401 CAH18246 DA109756 DQ891618 ABM82544 DQ894810 ABM85736 L77964 AAA98769 X80692 CAA56709 XM_005254536 XP_005254593 XM_005254537 XP_005254594 XM_005254538 XP_005254595 XM_005254539 XP_005254596 XM_011521782 XP_011520084 NM_002748 NP_002739
Function	Atypical MAPK protein. Phosphorylates microtubule- associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity). {ECO:0000250}.
Subcellular Location	Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Translocates to the cytoplasm following interaction with MAPKAPK5. {ECO:0000250}.
Tissue Specificity	Highest expression in the skeletal muscle, followed by the brain. Also found in heart, placenta, lung, liver, pancreas, kidney and skin fibroblasts.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ERK 3 CRISPR/Cas9 KO Plasmid (h) - sc-403457 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

ERK 3 HDR Plasmid (h) - sc-403457-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ERK 3 Double Nickase Plasmid (h) - sc-403457-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ERK 3 Double Nickase Plasmid (h2) - sc-403457-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ERK 3 CRISPR Activation Plasmid (h) - sc-403457-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

ERK 3 CRISPR Activation Plasmid (h2) - sc-403457-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

ERK 3 Lentiviral Activation Particles (h) - sc-403457-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ERK 3 Lentiviral Activation Particles (h2) - sc-403457-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

ERK 3 siRNA (h) - sc-35337 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

ERK 3 shRNA Plasmid (h) - sc-35337-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

ERK 3 shRNA (h) Lentiviral Particles - sc-35337-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

ERK3/MAPK6 RNAi - H00005597-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

ERK3/MAPK6 RNAi - H00005597-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU106121 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK1213 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1214 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1215 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN13014 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13014 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08621 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr08621

MAPK6 siRNA (Human) - CRH3767 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

Human MAPK6 siRNA - orb264269 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

MAPK6 shRNA Plasmid (Human) - CHH3767 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

MAPK6 miRNA 3'UTR clone - MiUTR3H-05397 from Creative biogene Species Reactivities Human

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