MAPK6

Gene Symbol MAPK6
Entrez Gene 5597
Alt Symbol ERK3, HsT17250, PRKM6, p97MAPK
Species Human
Gene Type protein-coding
Description mitogen-activated protein kinase 6
Other Description ERK-3|MAP kinase 6|MAP kinase isoform p97|MAPK 6|extracellular signal-regulated kinase 3|extracellular signal-regulated kinase, p97|p97-MAPK|protein kinase, mitogen-activated 5|protein kinase, mitogen-activated 6
Swissprots Q16659 B5BU65 Q8IYN8 Q68DH4 B2R945
Accessions EAW77434 Q16659 AB451301 BAG70115 AF420474 AAL17605 AK313633 BAG36392 BC035492 AAH35492 CR749401 CAH18246 DA109756 DQ891618 ABM82544 DQ894810 ABM85736 L77964 AAA98769 X80692 CAA56709 XM_005254536 XP_005254593 XM_005254537 XP_005254594 XM_005254538 XP_005254595 XM_005254539 XP_005254596 XM_011521782 XP_011520084 NM_002748 NP_002739
Function Atypical MAPK protein. Phosphorylates microtubule- associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Translocates to the cytoplasm following interaction with MAPKAPK5. {ECO:0000250}.
Tissue Specificity Highest expression in the skeletal muscle, followed by the brain. Also found in heart, placenta, lung, liver, pancreas, kidney and skin fibroblasts.

Erk3 Antibody - 4067 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from A431, MCF7, HeLa, C6, NIH/3T3 and C2C12 cells, using Erk3 Antibody.

ERK 3 (B-10) - sc-365234 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ERK 3 (B-10): sc-365234. Western blot analysis of ERK 3 expression in PC-12 whole cell lysate.

ERK 3 (G-2) - sc-393371 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ERK 3 (G-2): sc-393371. Western blot analysis of ERK 3 expression in PC-12 (A), K-562 (B), SJRH30 (C) and HeLa (D) whole cell lysates and KNRK nuclear extract (E).

ERK 3 (E-3) - sc-374239 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ERK 3 (E-3): sc-374239. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.

ERK 3 (I-15) - sc-156 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ERK 3 (I-15): sc-156. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human lung tumor.

ERK 3 (H-157) - sc-10787 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ERK 3 (H-157) PE: sc-10787 PE. Intracellular FCM analysis of fixed and permeabilized A431 cells. Black line histogram represents the isotype control, normal rabbit IgG: sc-3871.

ERK 3 (D-23) - sc-155 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ERK 3 (D-23) PE: sc-155 PE. Intracellular FCM analysis of fixed and permeabilized HeLa cells. Black line histogram represents the isotype control, normal rabbit IgG: sc-3871.

Anti-MAPK6 (phospho S189) antibody - ab74032 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using ab74032, at 1/50 dilution, in the presence (right panel) or absence (left panel) of immunising phosphopeptide.

Anti-MAPK6 antibody - ab95079 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1: 1mg HeLa whole cell lysate was immunoprecipitated with 3µg ab95079. 20% IP was loaded on gel and probed with 1µg/ml ab95079.Lane 2: same, using a control IgG Detection: chemiluminescence with exposure time of 30 seconds.

Anti-MAPK6 antibody - ab137902 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-MAPK6 antibody (ab137902) at 1/500 dilution + Jurkat cell lysate at 30 µg

Anti-MAPK6 antibody [5E1] - ab155934 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 5E1
All lanes : Anti-MAPK6 antibody [5E1] (ab155934) at 1/1000 dilutionLane 1 : HeLa whole cell lysateLane 2 : 293T whole cell lysateLane 3 : 3T3 whole cell lysateLysates/proteins at 25 µg per lane.SecondaryGoat anti-mouse HRP conjugated antibody at 1/15000 dilutiondeveloped using the ECL technique

Anti-MAPK6 antibody [5E1] - ab84993 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5E1
All lanes : Anti-MAPK6 antibody [5E1] (ab84993)Lane 1 : Lysate from HEK293T cells transfected with an empty expression vector (lysed after 48 hours) Lane 2 : Lysate from HEK293T cells transfected with an expression vector containing MAPK6 (lysed after 48 hours)Lysates/proteins at 5 µg per lane.

Anti-MAPK6 antibody [EP1720Y] - ab53277 from Abcam

Prices $391.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP1720Y
Overlay histogram showing A431 cells stained with ab53277 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab53277, 1/1000 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-rabbit IgG (H&L) (ab150077) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (0.1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-MAPK6 / ERK3 Antibody (Asp475) - LS-C177128 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of ERK3 (D475) pAb in extracts from K562 cells.

Anti-MAPK6 / ERK3 Antibody (aa395-444) - LS-C135383 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
MAPK6 antibody LS-C135383 Western blot of Transfected 293T cell lysate.

Anti-MAPK6 / ERK3 Antibody (aa155-204) - LS-C117892 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from HeLa cells, using p97 MAPK (Ab-189) Antibody. The lane on the right is treated with the synthesized peptide.

Anti-MAPK6 / ERK3 Antibody (Lys185) - LS-C177431 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of ERK3 (K185) pAb in extracts from HeLa cell.

Anti-MAPK6 / ERK3 Antibody (phospho-Ser189, AP) - LS-C213956 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAPK6 / ERK3 Antibody (phospho-Ser189, APC) - LS-C213957 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAPK6 / ERK3 Antibody (N-Terminus, clone EP1720Y) - LS-C49983 from LifeSpan Bioscience

Prices $490.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP1720Y
IHC of paraffin-embedded human breast carcinoma using anti-ERK3 antibody.

Anti-MAPK6 / ERK3 Antibody (phospho-Ser189, Biotin) - LS-C213958 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAPK6 / ERK3 Antibody (phospho-Ser189, FITC) - LS-C213959 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAPK6 / ERK3 Antibody (phospho-Ser189, Azide-free, HRP) - LS-C213961 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-MAPK6 / ERK3 Antibody (aa426-475) - LS-C200456 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of the lysates from HeLa cells using p97 MAPK antibody.

Anti-MAPK6 / ERK3 Antibody (aa136-185) - LS-C200455 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of the lysates from Jurkat cells using p97 MAPK antibody.
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