IFITM3

Gene Symbol IFITM3
Entrez Gene 10410
Alt Symbol 1-8U, DSPA2b, IP15
Species Human
Gene Type protein-coding
Description interferon induced transmembrane protein 3
Other Description dispanin subfamily A member 2b|interferon-induced transmembrane protein 3|interferon-inducible protein 1-8U
Swissprots Q01628 Q96J15 Q96HK8 Q53Y76
Accessions AFF60304 AFF60305 AFF60306 AFF60307 AFF60308 AFF60309 AFF60310 AFF60311 AFF60312 AFF60313 AFF60314 AFF60315 AFF60316 AFF60317 AFF60318 AFF60319 AFF60320 AFF60321 AFF60322 AFF60323 AFF60324 AFF60325 AFF60326 AFF60327 AFF60328 AFF60329 AFF60330 AFF60331 AFF60332 AFF60333 AFF60334 AFF60335 AFF60336 AFF60337 AFF60338 AFF60339 AFF60340 AFF60341 AFF60342 AFF60343 AFF60344 AFF60345 AFF60346 AFF60347 AFF60348 AFF60349 AFF60350 AFF60351 AFF60352 AFF60353 AFF60354 AFF60355 EAW50866 Q01628 AI355192 AK292173 BAF84862 AM392723 CAL37601 AM393694 CAL38570 BC006794 AAH06794 BC008417 AAH08417 BC022439 AAH22439 BC070243 AAH70243 BQ937265 BT006892 AAP35538 DB261103 DQ891098 ABM82024 DQ894280 ABM85206 X57352 CAA40626 NM_021034 NP_066362 NR_049759
Function IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2- mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localizatio
Subcellular Location Cell membrane; Single-pass type II membrane protein. Late endosome membrane; Single-pass type II membrane protein. Lysosome membrane; Single-pass type II membrane protein.

IFITM3 (A-24) - sc-130785 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
IFITM3 (A-24): sc-130785. Western blot analysis of IFITM3 expression in HeLa whole cell lysate.

IFITM3 (F-41) - sc-100768 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
IFITM3 (F-41): sc-100768. Western blot analysis of IFITM3 expression in non-transfected: sc-117752 (A) and human IFITM3 transfected: sc-110589 (B) 293T whole cell lysates.

Anti-Fragilis antibody - ab74699 from Abcam

Prices $379.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Fragilis antibody (ab74699) at 1/500 dilutionLane 1 : Extracts from HepG2 cells (5-30µg)Lane 2 : Extracts from HeLa cells (5-30µg)Lane 3 : Extracts from HeLa cells (5-30µg), plus immunising peptide (5-10µg)

Anti-Fragilis antibody - ab65183 from Abcam

Prices $378.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Fragilis antibody (ab65183) at 1/60 dilution + Hela cell line lysates at 35 µg

Anti-Fragilis antibody - ab56700 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-Fragilis antibody - ab172386 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-Fragilis antibody (ab172386) at 1 µg/mlLane 1 : Fragilis transfected 293T cell line lysateLane 2 : Non-transfected 293T cell line lysateSecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Anti-Fragilis antibody [EPR5242] - ab109429 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5242
All lanes : Anti-Fragilis antibody [EPR5242] (ab109429) at 1/1000 dilutionLane 1 : HeLa cell lysate Lane 2 : 293T cell lysate Lane 3 : Human placenta lysateLysates/proteins at 10 µg per lane.

Anti-Fragilis antibody [EPR5242] (Alexa Fluor® 488) - ab198559 from Abcam

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5242
ab198559 staining Fragilis in HepG2 cells. The cells were fixed with 4% formaldehyde (10 min), permeabilized with 0.1% Triton X-100 for 5 minutes and then blocked with 1% BSA/10% normal goat serum/0.3M glycine in 0.1% PBS-Tween for 1h. The cells were then incubated overnight at +4°C with ab198559 at a 1/100 dilution (shown in red) and ab195887, Mouse monoclonal to alpha Tubulin (Alexa Fluor® 488), at a 1/250 dilution (shown in green). Nuclear DNA was labelled with DAPI (shown in blue).Image was taken with a confocal microscope (Leica-Microsystems, TCS SP8).This product also gave a positive signal under the same testing conditions in HepG2 cells fixed with 100% methanol (5 min).

Anti-Fragilis antibody [EPR5242] (Alexa Fluor® 647) - ab198573 from Abcam

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5242
ab198573 staining Fragilis in HepG2 cells. The cells were fixed with 4% formaldehyde (10 min), permeabilized with 0.1% Triton X-100 for 5 minutes and then blocked with 1% BSA/10% normal goat serum/0.3M glycine in 0.1% PBS-Tween for 1h. The cells were then incubated overnight at +4°C with ab198573 at a 1/100 dilution (shown in red) and ab195887, Mouse monoclonal to alpha Tubulin (Alexa Fluor® 488), at a 1/250 dilution (shown in green). Nuclear DNA was labelled with DAPI (shown in blue).Image was taken with a confocal microscope (Leica-Microsystems, TCS SP8).This product also gave a positive signal under the same testing conditions in HepG2 cells fixed with 100% methanol (5 min).

Anti-Fragilis antibody [EPR5242] (HRP) - ab199021 from Abcam

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5242
Anti-Fragilis antibody [EPR5242] (HRP) (ab199021) at 1/5000 dilution + HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate (ab150035)developed using the ECL techniquePerformed under reducing conditions.

Anti-Fragilis / IFITM3 Antibody (aa3-57) - LS-C182879 from LifeSpan Bioscience

Prices $650.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-Fragilis / IFITM3 Antibody (aa47-58) - LS-C148024 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-Fragilis / IFITM3 Antibody (clone 4C8-1B10) - LS-C308394 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4C8-1B10

Anti-Fragilis / IFITM3 Antibody - LS-C310705 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Fragilis / IFITM3 Antibody (aa9-54) - LS-C313795 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Fragilis / IFITM3 Antibody - LS-C310708 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Fragilis / IFITM3 Antibody (aa1-50) - LS-C19391 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of fragilis in NIH 3T3 cell lysate in the (A) absence and (B) presence of immunizing peptide using antibody at1 ug/ml.

Anti-Fragilis / IFITM3 Antibody (Internal, clone EPR5242) IHC-plus™ - LS-B7510 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5242
Anti-IFITM3 antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7510 dilution 1:50.

Anti-Fragilis / IFITM3 Antibody (aa1-50) - LS-C119528 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of MCF7 cells, using IFM3 Antibody. The picture on the right is treated with the synthesized peptide.

Anti-Fragilis / IFITM3 Antibody (aa64-93) - LS-C98677 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of anti-IFITM3 Antibody in HeLa cell line lysates (35 ug/lane). IFITM3(arrow) was detected using the purified antibody.

Anti-Fragilis / IFITM3 Antibody (aa1-30) - LS-C98676 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Fluorescent confocal image of HeLa cells stained with IFITM3 antibody. HeLa cells were fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.2%, 30 min), then incubated with Fragilis (IFITM3) primary antibody (1:200, 2 h at room temperature). For secondary antibody, Alexa Fluor 488 conjugated donkey anti-rabbit antibody (green) was used (1:1000, 1h). Cytoplasmic actin was counterstained with Alexa Fluor 555 (red) conjugated Phalloidin (5.25 mu M, 25 min). Nuclei were counterstained with Hoechst 33342 (blue) (10 ug/ml, 3 min). Note the highly specific localization of the IFITM3 immunoreactivity to the Golgi.

Anti-Fragilis / IFITM3 Antibody IHC-plus™ - LS-B9383 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Fragilis / IFITM3 antibody IHC staining of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IFITM3/Fragilis Antibody (EPR5242) - NBP1-95757 from Novus Biologicals

Host Rabbit
Clonality Monoclonal
Clone EPR5242
Western Blot: IFITM3 Antibody (EPR5242) [NBP1-95757] - Whole cell extract from HeLa (uninduced) and induced with IFN-beta (100U/mL). IFITM3 antibody diluted 1:10000. Image and data from confirmed customer review.

IFITM2/IFITM3 Antibody - AF4834 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Western Blot IFITM2/IFITM3 Antibody

IFITM3/Fragilis Antibody - H00010410-D03P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: IFITM3 Antibody [H00010410-D03P] - IFITM3 MaxPab rabbit polyclonal antibody. Western Blot analysis of IFITM3 expression in mouse lung.
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