HTRA2

Gene Symbol	HTRA2
Entrez Gene	27429
Alt Symbol	OMI, PARK13, PRSS25
Species	Human
Gene Type	protein-coding
Description	HtrA serine peptidase 2
Other Description	HtrA-like serine protease|Omi stress-regulated endoprotease|high temperature requirement protein A2|protease, serine, 25|serine protease 25|serine protease HTRA2, mitochondrial|serine proteinase OMI
Swissprots	O43464 Q9HBZ4 Q9P0Y4 Q9P0Y3
Accessions	ABU25433 EAW99617 EAW99618 EAW99619 EAW99620 EAW99621 O43464 AF020760 AAB94569 AF141305 AAF66596 AF141306 AAF66597 AF141307 AAF66598 AF184911 AAG13126 AK225932 AK291977 BAF84666 AK310163 BC000096 AAH00096 BF939362 DQ891822 ABM82748 DQ895009 ABM85935 EU176308 ABW03759 XM_005264266 XP_005264323 NM_013247 NP_037379 NM_145074 NP_659540
Function	Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive. {ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:19502560}.
Subcellular Location	Mitochondrion intermembrane space. Mitochondrion membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Note=Predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment, and stimulation of mitochondria with caspase-8 truncated BID/tBID.
Tissue Specificity	Isoform 1 is ubiquitous. Isoform 2 is expressed predominantly in the kidney, colon and thyroid.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

HTRA2 Human ELISA Kit - ab155434 from Abcam Category ELISA Kit Prices $499.00 Sizes 1 x 96 tests Sensitivity < 0.2 ng/ml Range 0.205 ng/ml - 50 ng/ml

Human HTRA2 / OMI ELISA Kit (Sandwich ELISA) - LS-F101 from LifeSpan Bioscience Category ELISA Kit Prices $620.00, $1,090.00, $2,380.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 0.205 ng/ml Range 0.205-20 ng/ml

Human HTRA2 ELISA Kit - RAB0218 from Sigma-Aldrich Category ELISA Kit

Quantikine Immunoassay Control Set 792 for Human HTRA2/Omi - QC103 from R&D Systems Category ELISA Kit Prices $125.00 Sizes 1 each

Human HTRA2/Omi Quantikine ELISA Kit - DHTR20 from R&D Systems Category ELISA Kit Prices $509.00 Sizes 1 kit Sensitivity 13.2 pg/mL Range 31.3 - 2,000 pg/mL (Cell Culture Supernates, Serum, Platelet-poor EDTA Plasma, Platelet-poor Heparin Plasma)

Human HTRA2 ELISA - ELH-HTRA2 from RayBiotech Category ELISA Kit Prices $560.00, $1,008.00, $2,241.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit Sensitivity 200 pg/ml Range 0.2 ng/ml - 50 ng/ml

HtrA serine peptidase 2, ELISA Kit - MBS9321609 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

HtrA Serine Peptidase 2 (HTRA2), ELISA Kit - MBS9302742 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human HTRA2 ELISA kit - DEIA5453 from Creative Diagnostics Category ELISA Kit Sensitivity 0.2 ng/mL

Human Serine protease HTRA2, mitochondrial ELISA Kit - EKE55399 from Biomatik Category ELISA Kit Prices $809.60, $3,440.80, $6,476.80 Sizes 96 t, 5x96t, 10x96t Range 0.156-10 ng/ml

Human HTRA2 ELISA - ELH-HTRA2-1 from RayBiotech Category ELISA Kit Prices $571.00, $1,027.80, $2,284.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Human HtrA2/Omi ELISA Kit - E018656 from Biobool Category ELISA Kit

Human HTRA2 ELISA Kit - E019022 from Biobool Category ELISA Kit

HTRA2 ELISA Kit (Human) (OKEH03514) - OKEH03514 from Aviva Systems Biology Category ELISA Kit Prices $485.00 Sizes 96 wells Sensitivity 0.078 ng/mL Range 0.156 - 10 ng/mL

Human Serine protease HTRA2, mitochondrial ELISA Kit - EK3702 from Signalway Antibody Category ELISA Kit Prices $739.00 Sizes 1x96t Range 0.156-10 ng/ml

anti-HtrA2 / Omi antibody - ARG55916 from Arigo Biolaboratories Category ELISA Kit

anti-HtrA2 / Omi antibody [3F9] - ARG57139 from Arigo Biolaboratories Category ELISA Kit

Serine protease HTRA2, ELISA Kit - MBS2888039 from MyBioSource Category ELISA Kit Prices $430.00, $570.00, $2,515.00, $4,520.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Serine protease HTRA2, ELISA Kit - MBS9427533 from MyBioSource Category ELISA Kit Prices $670.00 Sizes 96 tests Range 0.156-10 ng/mL

Serine protease HTRA2, ELISA Kit - MBS2888038 from MyBioSource Category ELISA Kit Prices $430.00, $570.00, $2,515.00, $4,520.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 0.156-10 ng/ml

Serine protease HTRA2, ELISA Kit - MBS2888040 from MyBioSource Category ELISA Kit Prices $430.00, $570.00, $2,515.00, $4,520.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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