HTRA2

Gene Symbol	HTRA2
Entrez Gene	27429
Alt Symbol	OMI, PARK13, PRSS25
Species	Human
Gene Type	protein-coding
Description	HtrA serine peptidase 2
Other Description	HtrA-like serine protease|Omi stress-regulated endoprotease|high temperature requirement protein A2|protease, serine, 25|serine protease 25|serine protease HTRA2, mitochondrial|serine proteinase OMI
Swissprots	O43464 Q9HBZ4 Q9P0Y4 Q9P0Y3
Accessions	ABU25433 EAW99617 EAW99618 EAW99619 EAW99620 EAW99621 O43464 AF020760 AAB94569 AF141305 AAF66596 AF141306 AAF66597 AF141307 AAF66598 AF184911 AAG13126 AK225932 AK291977 BAF84666 AK310163 BC000096 AAH00096 BF939362 DQ891822 ABM82748 DQ895009 ABM85935 EU176308 ABW03759 XM_005264266 XP_005264323 NM_013247 NP_037379 NM_145074 NP_659540
Function	Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive. {ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:19502560}.
Subcellular Location	Mitochondrion intermembrane space. Mitochondrion membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Note=Predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment, and stimulation of mitochondria with caspase-8 truncated BID/tBID.
Tissue Specificity	Isoform 1 is ubiquitous. Isoform 2 is expressed predominantly in the kidney, colon and thyroid.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human HtrA2 / Omi full length protein - ab48747 from Abcam Category Protein Source E. coli Species Human

Human HtrA2 / Omi full length protein - ab73437 from Abcam Category Protein Source E. coli Species Human

Human HtrA2 / Omi peptide - ab39838 from Abcam Category Peptide Species Human

HTRA2 / OMI Antibody Blocking Peptide - LS-E2635 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HTRA2 / OMI Antibody Blocking Peptide - LS-E30003 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

HTRA2 / OMI Antibody Blocking Peptide - LS-E30069 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

HTRA2/Omi Partial Recombinant Protein - H00027429-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human HTRA2/Omi Protein - NBC1-18522 from Novus Biologicals Category Protein Prices $229.00 Sizes 100 µg Source E.coli Species Human

HTRA2/Omi Blocking Peptide - NBP1-77195PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

HTRA2/Omi Blocking Peptide - NBP1-76637PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

HTRA2/Omi Recombinant Protein - P3519 from Novus Biologicals Category Protein Prices $449.00 Sizes 100 µg Species Human

HTRA2-Antibody-N-term-Blocking-peptide - BP13705a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human HTRA2/Omi, CF - 1458-HT-100 from R&D Systems Category Protein Source E. coli-derived, Ala134-Glu458, with a C-terminal 6-His tag

HTRA2 Protein (OPPA00851) - OPPA00851 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 10 µg Source E. Coli

Human HTRA2 protein - orb90150 from Biorbyt Category Protein Prices $230.00, $442.00 Sizes 10 μg, 50 μg Source E.coli Species Human

Human HTRA2 His tag protein - orb84384 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 100 μg, 200 μg Source E. coli Species Human

HtrA2 Blocking Peptide - 33R-10784 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

HtrA2/Omi protein (His tag) - 80R-1010 from Fitzgerald Category Protein Prices $180.00 Sizes 100 µg Source E.coli

HTRA2 / PRSS25 (134-458, His-tag) - SA6060 from Acris Antibodies Category Protein Prices $270.00 Sizes 100 µg Source E. coli Species Human

HTRA2 / PRSS25 (134-458, His-tag) - SA6060X from Acris Antibodies Category Protein Prices $585.00 Sizes 500 µg Source E. coli Species Human

HTRA2 / PRSS25 - H00027429-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

HTRA2 / PRSS25 - H00027429-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

HTRA2 / PRSS25 - P3519 from Acris Antibodies Category Protein Prices $430.00 Sizes 100 µg Species Human

HTRA2 / PRSS25 Control Peptide - AP30627CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

HTRA2 / PRSS25 Control Peptide - AP30628CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

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