HTRA2

Gene Symbol	HTRA2
Entrez Gene	27429
Alt Symbol	OMI, PARK13, PRSS25
Species	Human
Gene Type	protein-coding
Description	HtrA serine peptidase 2
Other Description	HtrA-like serine protease|Omi stress-regulated endoprotease|high temperature requirement protein A2|protease, serine, 25|serine protease 25|serine protease HTRA2, mitochondrial|serine proteinase OMI
Swissprots	O43464 Q9HBZ4 Q9P0Y4 Q9P0Y3
Accessions	ABU25433 EAW99617 EAW99618 EAW99619 EAW99620 EAW99621 O43464 AF020760 AAB94569 AF141305 AAF66596 AF141306 AAF66597 AF141307 AAF66598 AF184911 AAG13126 AK225932 AK291977 BAF84666 AK310163 BC000096 AAH00096 BF939362 DQ891822 ABM82748 DQ895009 ABM85935 EU176308 ABW03759 XM_005264266 XP_005264323 NM_013247 NP_037379 NM_145074 NP_659540
Function	Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive. {ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:19502560}.
Subcellular Location	Mitochondrion intermembrane space. Mitochondrion membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Note=Predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment, and stimulation of mitochondria with caspase-8 truncated BID/tBID.
Tissue Specificity	Isoform 1 is ubiquitous. Isoform 2 is expressed predominantly in the kidney, colon and thyroid.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® HtrA2/Omi siRNA I - 7574 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

HtrA2 CRISPR/Cas9 KO Plasmid (h) - sc-402576 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

HtrA2 HDR Plasmid (h) - sc-402576-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

HtrA2 Double Nickase Plasmid (h) - sc-402576-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

HtrA2 Double Nickase Plasmid (h2) - sc-402576-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

HtrA2 CRISPR Activation Plasmid (h) - sc-402576-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

HtrA2 CRISPR Activation Plasmid (h2) - sc-402576-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

HtrA2 Lentiviral Activation Particles (h) - sc-402576-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

HtrA2 Lentiviral Activation Particles (h2) - sc-402576-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

HtrA2 siRNA (h) - sc-35615 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

HtrA2 shRNA Plasmid (h) - sc-35615-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

HtrA2 shRNA (h) Lentiviral Particles - sc-35615-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

HTRA2/Omi RNAi - H00027429-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

HTRA2/Omi RNAi - H00027429-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU151841 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN2383 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2383 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR04537 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr04537

HTRA2 siRNA (Human) - CRH9102 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

HTRA2 - MBS8240245 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human HTRA2(NM_145074.2) - SHH136397 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human HTRA2(NM_013247.4) - SHH136433 from Creative biogene Category siRNA Species Reactivities Human

OMI siRNA - orb219201 from Biorbyt Category siRNA Prices $417.00 Sizes 5 od (260 nm) Species Reactivities Human

HTRA2 shRNA Plasmid (Human) - CHH9102 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

HTRA2 miRNA 3'UTR clone - MiUTR1H-04759 from Creative biogene Species Reactivities Human

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