HTRA2

Gene Symbol HTRA2
Entrez Gene 27429
Alt Symbol OMI, PARK13, PRSS25
Species Human
Gene Type protein-coding
Description HtrA serine peptidase 2
Other Description HtrA-like serine protease|Omi stress-regulated endoprotease|high temperature requirement protein A2|protease, serine, 25|serine protease 25|serine protease HTRA2, mitochondrial|serine proteinase OMI
Swissprots O43464 Q9HBZ4 Q9P0Y4 Q9P0Y3
Accessions ABU25433 EAW99617 EAW99618 EAW99619 EAW99620 EAW99621 O43464 AF020760 AAB94569 AF141305 AAF66596 AF141306 AAF66597 AF141307 AAF66598 AF184911 AAG13126 AK225932 AK291977 BAF84666 AK310163 BC000096 AAH00096 BF939362 DQ891822 ABM82748 DQ895009 ABM85935 EU176308 ABW03759 XM_005264266 XP_005264323 NM_013247 NP_037379 NM_145074 NP_659540
Function Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive. {ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:19502560}.
Subcellular Location Mitochondrion intermembrane space. Mitochondrion membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Note=Predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment, and stimulation of mitochondria with caspase-8 truncated BID/tBID.
Tissue Specificity Isoform 1 is ubiquitous. Isoform 2 is expressed predominantly in the kidney, colon and thyroid.

HtrA2/Omi (D20A5) Rabbit mAb - 9745 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D20A5
Western blot analysis of extracts from various cell lines using HtrA2/Omi (D20A5) Rabbit mAb.

HtrA2 Antibody - 2176 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HT1080, Raji and BaF3 cell lines, using HtrA2 Antibody.

HtrA2 (E-3) - sc-365594 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
HtrA2 (E-3): sc-365594. Western blot analysis of HtrA2 expression in Jurkat whole cell lysate.

HtrA2 (C-10) - sc-271528 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
HtrA2 (C-10): sc-271528. Western blot analysis of HtrA2 expression in HL-60 (A), Jurkat (B) and TT (C) whole cell lysates.

HtrA2 (H-60) - sc-25606 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
HtrA2 (H-60): sc-25606. Western blot analysis of HtrA2 precursor expression in HL-60 (A), Jurkat (B), TT (C), COLO 320DM (D) and Caki-1 (E) whole cell lysates.

HtrA2 (V-17) - sc-15467 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
HtrA2 (V-17): sc-15467. Western blot analysis of HtrA2 precursor expression in mouse placenta (A) and rat placenta (B) extracts and mature HtrA2 in mouse Lac Z whole cell lysate (C).

HtrA2 (P-15) - sc-31814 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
HtrA2 (P-15): sc-31814. Western blot analysis of human recombinant HtrA2.

HtrA2 (L-14) - sc-31816 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
HtrA2 (L-14): sc-31816. Western blot analysis of HtrA2 expression in HL-60 (A), Jurkat (B) and COLO 320DM (C) whole cell lysates and mouse brain tissue extract (D).

HtrA2 (1B3) - sc-58371 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
HtrA2 (1B3): sc-58371. Western blot analysis of HtrA2 expression in 293T (A), MCF7 (B), HT-29 (C), HL-60 (D) and HeLa (E) whole cell lysates and mouse brain (F) and rat brain (G) tissue extracts.

Anti-HtrA 1 + 2 + 3 + 4 antibody - ab22112 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-HtrA 1 + 2 + 3 + 4 antibody (ab22112) at 3 µg/mlLane 1 : Human heart lysateLane 2 : Mouse heart lysateLane 3 : Rat heart lysate

Anti-HtrA2 / Omi antibody - ab36854 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-HtrA2 / Omi antibody (ab36854) at 1 µg/ml + U937 cell lysate

Anti-HtrA2 / Omi antibody - ab21307 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of HtrA2 / Omi in Human colon tissue with ab21307 at 20 ug/mL.

Anti-HtrA2 / Omi antibody - ab18895 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HtrA2 / Omi antibody - ab65906 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-HtrA2 / Omi antibody (ab65906) at 1/1000 dilutionLane 1 : Molecular weight markersLane 2 : HEK-293 with TNF alpha in Complete MediumLane 3 : HFL-1 in Complete Medium in Serum Free condition Lane 4 : HFL-1 in Complete Medium with TPALane 5 : HFL-1 in Complete Medium with IL 1-BetaLane 6 : HFL-1 in Complete Medium with Beta-estradiolLane 7 : HFL-1 in Complete Medium with Progesterone

Anti-HtrA2 / Omi antibody - ab65908 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-HtrA2 / Omi antibody (ab65908) at 1/1000 dilutionLane 1 : Molecular weight markersLane 2 : HeLa in complete medium with Serum FreeLane 3 : HeLa in Complete Medium, treatment with TPALane 4 : HeLa Complete Medium, treatment with Retinoic AcidLane 5 : HeLa in Complete Medium, treatment with Beta-EstradiolLane 6 : HeLa in Complete Medium, treatment with Progesterone

Anti-HtrA2 / Omi antibody [196C429] - ab13678 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 196C429

Anti-HtrA2 / Omi antibody [1B3] - ab33041 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1B3

Anti-HtrA2 / Omi antibody [E55] - ab32092 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone E55
Anti-HtrA2 / Omi antibody [E55] (ab32092) at 1/2000 dilution + Jurkat cell lysate.

Anti-HtrA2 / Omi antibody [EPR22] - ab75982 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR22
Overlay histogram showing HeLa cells stained with ab75982 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab75982, 1/100 dilution) for 30 min at 22°C. The secondary antibody used was goat anti-rabbit Alexa Fluor® 488 (IgG H+L) (ab150077) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-HtrA2 / Omi antibody - C-terminal - ab189307 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-HtrA2 / Omi antibody - C-terminal (ab189307) at 0.5 µg/mlLane 2 : Anti-HtrA2 / Omi antibody - C-terminal (ab189307) at 1 µg/mlLane 1 : Human colon lysateLane 2 : Human colon lysate

Anti-HtrA2 / Omi antibody - Carboxyterminal end - ab65909 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-HtrA2 / Omi antibody - Carboxyterminal end (ab65909) at 1/1000 dilutionLane 1 : SW 620 in Complete Medium, treatment with TNF-alphaLane 2 : SW 620 in Complete Medium, treatment with TPALane 3 : SW 620 in Complete Medium, treatment with IL 1-BetaLane 4 : Molecular weight markers

Anti-HtrA2 / Omi antibody - Catalytic domain - ab65907 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-HtrA2 / Omi antibody - Catalytic domain (ab65907) at 1/1000 dilutionLane 1 : Molecular weight markersLane 2 : HeLa lysate in serum free condition at 10 µlLane 3 : HeLa lysate treated with TPA at 10 µlLane 4 : HeLa lysate treated with Retinoic Acid at 10 µlLane 5 : HeLa lysate treated with Beta-Estradiol at 10 µlLane 6 : HeLa lysate treated with Progesterone at 10 µl

Anti-HTRA2 / OMI Antibody (C-Terminus) - LS-C9396 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HTRA2 / OMI Antibody (C-Terminus) - LS-C9399 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HTRA2 / OMI Antibody - LS-C37869 from LifeSpan Bioscience

Prices $355.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Search more