POFUT1

Gene Symbol	POFUT1
Entrez Gene	23509
Alt Symbol	DDD2, FUT12, O-FUT, O-Fuc-T, O-FucT-1, OFUCT1
Species	Human
Gene Type	protein-coding
Description	protein O-fucosyltransferase 1
Other Description	GDP-fucose protein O-fucosyltransferase 1|o-fucosyltransferase protein|peptide-O-fucosyltransferase 1
Swissprots	Q5W185 Q9BW76 Q9H488 Q14685 E1P5M4 A8K4R8
Accessions	EAW76383 EAW76384 EAW76385 Q9H488 AF375884 AAL09576 AK291033 BAF83722 AK300810 BAG62466 AK303068 BAG64185 AL832023 BC000582 AAH00582 BC017669 D80002 BAA11497 XR_430297 NM_015352 NP_056167 NM_172236 NP_758436
Function	Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP-fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that can then extend the fucosylation on the NOTCH EGF repeats. This extended fucosylation is required for optimal ligand binding and canonical NOTCH signaling induced by DLL1 or JAGGED1. Fucosylates AGRN and determines its ability to cluster acetylcholine receptors (AChRs). {ECO:0000269|PubMed:11524432, ECO:0000269|PubMed:8358148}.
Subcellular Location	Endoplasmic reticulum {ECO:0000250}.
Tissue Specificity	Highly expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:11524432}.
Top Pathways	Other types of O-glycan biosynthesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

POFUT1 overexpression lysate - LY406756 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

POFUT1 293 Cell Lysate - 407001 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

Protein O-Fucosyltransferase 1/POFUT1 Overexpression Lysate (Native) - NBP2-07188 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

POFUT1 Over-expression Lysate Product - GWB-E638CA from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Protein O-Fucosyltransferase 1/POFUT1 Overexpression Lysate (Native) - NBP2-05172 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Protein O-Fucosyltransferase 1/POFUT1 Overexpression Lysate (Denatured) - H00023509-T02 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Panoply™ Human POFUT1 Knockdown Stable Cell Line - CSC-DC012057 from Creative biogene Category Cell Line Species Human

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