POFUT1

Gene Symbol	POFUT1
Entrez Gene	23509
Alt Symbol	DDD2, FUT12, O-FUT, O-Fuc-T, O-FucT-1, OFUCT1
Species	Human
Gene Type	protein-coding
Description	protein O-fucosyltransferase 1
Other Description	GDP-fucose protein O-fucosyltransferase 1|o-fucosyltransferase protein|peptide-O-fucosyltransferase 1
Swissprots	Q5W185 Q9BW76 Q9H488 Q14685 E1P5M4 A8K4R8
Accessions	EAW76383 EAW76384 EAW76385 Q9H488 AF375884 AAL09576 AK291033 BAF83722 AK300810 BAG62466 AK303068 BAG64185 AL832023 BC000582 AAH00582 BC017669 D80002 BAA11497 XR_430297 NM_015352 NP_056167 NM_172236 NP_758436
Function	Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue found in the consensus sequence C2-X(4,5)-[S/T]-C3 of EGF domains, where C2 and C3 are the second and third conserved cysteines. Specifically uses GDP-fucose as donor substrate and proper disulfide pairing of the substrate EGF domains is required for fucose transfer. Plays a crucial role in NOTCH signaling. Initial fucosylation of NOTCH by POFUT1 generates a substrate for FRINGE/RFNG, an acetylglucosaminyltransferase that can then extend the fucosylation on the NOTCH EGF repeats. This extended fucosylation is required for optimal ligand binding and canonical NOTCH signaling induced by DLL1 or JAGGED1. Fucosylates AGRN and determines its ability to cluster acetylcholine receptors (AChRs). {ECO:0000269|PubMed:11524432, ECO:0000269|PubMed:8358148}.
Subcellular Location	Endoplasmic reticulum {ECO:0000250}.
Tissue Specificity	Highly expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:11524432}.
Top Pathways	Other types of O-glycan biosynthesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Pofut1 full length protein - ab139789 from Abcam Category Protein Source E. coli Species Human

POFUT1 Antibody Blocking Peptide - LS-E1910 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

POFUT1 Antibody Blocking Peptide - LS-E21744 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

POFUT1 Antibody Blocking Peptide - LS-E30557 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

POFUT1 Antibody Blocking Peptide - LS-E27896 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Protein O-Fucosyltransferase 1/POFUT1 Recombinant Protein - H00023509-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Protein O-Fucosyltransferase 1/POFUT1 Partial Recombinant Protein - H00023509-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Protein O-Fucosyltransferase 1/POFUT1 Protein - NBP2-23378 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

Protein O-Fucosyltransferase 1/POFUT1 Blocking Peptide - NBP1-76940PEP from Novus Biologicals Category Protein Prices $129.00 Sizes 50 µg Species Human

POFUT1-Antibody-C-term-Blocking-peptide - BP12747b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Protein O-fucosyltransferase 1/POFUT1, CF - 7409-GT-020 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Gly27-Leu384, with N-terminal human CD33 signal sequence and HA (YPYDVPDYA) tag

Human POFUT1 protein - orb169047 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E. coli

POFUT1 Blocking Peptide - 33R-8250 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

POFUT1 protein (His tag) - 80R-2617 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

POFUT1 Blocking Peptide - abx063773 from Abbexa Category Peptide Species Human, Dog, Monkey, Pig

POFUT1 (His-tag) - AR50737PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

POFUT1 (His-tag) - AR50737PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

POFUT1 - H00023509-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

POFUT1 - H00023509-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

POFUT1 - H00023509-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

POFUT1 - H00023509-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

POFUT1 Control Peptide - AP30683CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

POFUT1, 27-388aa Human, His tag, E.coli - 01-P1913 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

POFUT1 Peptide - 4765P from ProSci Category Peptide Species Human

POFUT1 fusion protein - ag6721 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

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