| Gene Symbol |
MAP1LC3C
|
| Entrez Gene |
440738
|
| Alt Symbol |
ATG8J, LC3C
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
microtubule-associated protein 1 light chain 3 gamma
|
| Other Description |
LC3-like protein 2|MAP1 light chain 3-like protein 2|MAP1 light chain 3-like protein 3|MAP1A/MAP1B LC3 C|MAP1A/MAP1B light chain 3 C|autophagy-related protein LC3 C|autophagy-related ubiquitin-like modifier LC3 C|microtubule-associated proteins 1A/1B light chain 3C
|
| Swissprots |
A0PJY8 Q9BXW4 A2RUP0
|
| Accessions |
EAW70108 Q9BXW4 AF276659 AAK35152 BC127722 AAI27723 BC132986 AAI32987 BC132988 AAI32989 CN260933 XM_005273139 XP_005273196 NM_001004343 NP_001004343
|
| Function |
Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruites all ATG8 family members to infecting bacteria such as S.Typhimurium. {ECO:0000269|PubMed:23022382}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12740394}. Endomembrane system {ECO:0000269|PubMed:12740394}; Lipid-anchor {ECO:0000269|PubMed:12740394}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:12740394}; Lipid-anchor {ECO:0000269|PubMed:12740394}. Note=LC3-II binds to the autophagic membranes.
|
| Tissue Specificity |
Most abundant in placenta, lung and ovary. {ECO:0000269|PubMed:12740394}.
|