Gene Symbol | MAP1LC3C |
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Entrez Gene | 440738 |
Alt Symbol | ATG8J, LC3C |
Species | Human |
Gene Type | protein-coding |
Description | microtubule-associated protein 1 light chain 3 gamma |
Other Description | LC3-like protein 2|MAP1 light chain 3-like protein 2|MAP1 light chain 3-like protein 3|MAP1A/MAP1B LC3 C|MAP1A/MAP1B light chain 3 C|autophagy-related protein LC3 C|autophagy-related ubiquitin-like modifier LC3 C|microtubule-associated proteins 1A/1B light chain 3C |
Swissprots | A0PJY8 Q9BXW4 A2RUP0 |
Accessions | EAW70108 Q9BXW4 AF276659 AAK35152 BC127722 AAI27723 BC132986 AAI32987 BC132988 AAI32989 CN260933 XM_005273139 XP_005273196 NM_001004343 NP_001004343 |
Function | Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruites all ATG8 family members to infecting bacteria such as S.Typhimurium. {ECO:0000269|PubMed:23022382}. |
Subcellular Location | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12740394}. Endomembrane system {ECO:0000269|PubMed:12740394}; Lipid-anchor {ECO:0000269|PubMed:12740394}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:12740394}; Lipid-anchor {ECO:0000269|PubMed:12740394}. Note=LC3-II binds to the autophagic membranes. |
Tissue Specificity | Most abundant in placenta, lung and ovary. {ECO:0000269|PubMed:12740394}. |
MAP LC3γ CRISPR/Cas9 KO Plasmid (h) - sc-406161 from Santa Cruz Biotechnology
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MAP LC3γ HDR Plasmid (h) - sc-406161-HDR from Santa Cruz Biotechnology
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MAP LC3γ Double Nickase Plasmid (h) - sc-406161-NIC from Santa Cruz Biotechnology
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MAP LC3γ Double Nickase Plasmid (h2) - sc-406161-NIC-2 from Santa Cruz Biotechnology
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MAP LC3γ CRISPR Activation Plasmid (h) - sc-406161-ACT from Santa Cruz Biotechnology
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MAP LC3γ CRISPR Activation Plasmid (h2) - sc-406161-ACT-2 from Santa Cruz Biotechnology
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MAP LC3γ Lentiviral Activation Particles (h) - sc-406161-LAC from Santa Cruz Biotechnology
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MAP LC3γ Lentiviral Activation Particles (h2) - sc-406161-LAC-2 from Santa Cruz Biotechnology
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MAP LC3γ siRNA (h) - sc-88776 from Santa Cruz Biotechnology
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MAP LC3γ shRNA Plasmid (h) - sc-88776-SH from Santa Cruz Biotechnology
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MAP LC3γ shRNA (h) Lentiviral Particles - sc-88776-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN12980 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12980 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06060 from Sigma-Aldrich
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MAP1LC3C siRNA (Human) - CRJ8266 from Cohesion Biosciences
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shRNA set against Human MAP1LC3C (NM_001004343.2) - SHH337499 from Creative biogene
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MAP1LC3C shRNA Plasmid (Human) - CHJ8266 from Cohesion Biosciences
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MAP1LC3C miRNA 3'UTR clone - MiUTR4H-TG05328 from Creative biogene
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