HFE

Gene Symbol HFE
Entrez Gene 3077
Alt Symbol HFE1, HH, HLA-H, MVCD7, TFQTL2
Species Human
Gene Type protein-coding
Description hemochromatosis
Other Description MHC class I-like protein HFE|hereditary hemochromatosis protein|hereditary hemochromatosis protein HLA-H|high Fe
Swissprots Q9HC83 Q96KU7 O75929 B2CKL0 Q96KU6 Q17RT0 Q96KU5 Q9HC70 Q9HC68 Q30201 Q9HC64 O75931 Q96KU8 O75930
Accessions AAB82083 AAD00449 AAF01222 AAK16502 AAM82608 AAM91950 ACB21042 AEB15974 AEX30801 AEX30802 AEX30803 AEX30804 AEX30805 AEX30806 AEX30807 AEX30808 AEX30809 AEX38002 AEX38003 AEX91880 AEX91881 AEX91882 AEX91883 AEX91884 AEX91885 AEY71945 AEY71947 AEY71948 AEY71949 AEY71950 AEY71951 AFI39663 AFI39664 AFI39665 AFI39666 AFI39667 AFI39668 AFI39669 AFI39670 AFI39671 AFI39672 AFI39673 AFI39674 AFI39675 AFI39676 AFI39677 AFI39678 AFI39679 AFI39680 AFI39681 AFI39682 AFI39683 AFI39685 AFI39686 AFP66572 AFU50508 AFU50509 AFU50510 AFU50511 AFU50512 AIS82617 AIS82618 AIS82619 AIS82620 AIS82621 AIS82622 AIS82623 AIS82624 AIS82625 AIS82626 AIS82627 AIS82628 AIS82629 AIS82630 AIS82631 AIS82632 AIS82633 CAA70934 CAB07442 CAJ42862 EAW55516 EAW55517 EAW55518 EAW55519 EAW55520 EAW55521 EAW55522 EAW55523 EAW55524 EAW55525 EAW55526 EAW55527 Q30201 AF079407 AAC62646 AF079408 AAC62647 AF079409 AAC62648 AF109385 AAD52104 AF115264 AAG29571 AF115265 AAG29572 AF144240 AAG29575 AF144242 AAG29577 AF147392 AF149804 AAG29342 AJ249335 CAC67792 AJ249336 CAC67793 AJ249337 CAC67794 AJ249338 CAC67795 AJ250635 CAC80805 AJ298839 AJ298840 AJ404378 AK293393 BAG56902 AK300933 BAG62562 AK316502 BAH14873 AY205604 AAO47091 BC074721 AAH74721 BC117201 AAI17202 BC117203 AAI17204 BC143887 HQ258197 ADR82951 JN375752 AEO50365 JN375753 AEO50366 JN375754 AEO50367 JN375755 AEO50368 JN375756 AEO50369 JN375757 AEO50370 JN375758 AEO50371 JN375759 AEO50372 U60319 AAC51823 XM_011514543 XP_011512845 XM_011514544 XP_011512846 XR_241893 NM_000410 NP_000401 NM_001300749 NP_001287678 NM_139003 NP_620572 NM_139004 NP_620573 NM_139006 NP_620575 NM_139007 NP_620576 NM_139008 NP_620577 NM_139009 NP_620578 NM_139010 NP_620579 NM_139011 NP_620580 NM_139002 NM_139005
Function Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin. {ECO:0000269|PubMed:9465039}.
Subcellular Location Membrane; Single-pass type I membrane protein.
Tissue Specificity Expressed in all tissues tested except brain.

HFE (C-12) - sc-514405 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
HFE (C-12): sc-514405. Western blot analysis of HFE expression in HeLa (A), A-431 (B) and Caco-2 (C) whole cell lysates and human liver tissue extract (D).

HFE (W-24) - sc-133654 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Rabbit
Clonality Polyclonal
HFE (W-24): sc-133654. Western blot analysis of HFE expression in Hep G2 whole cell lysate (A) and human liver tissue extract (B).

HFE (H-54) - sc-368717 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

HFE (K-16) - sc-18807 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

HFE (44-H) - sc-130375 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
HFE (44-H): sc-130375. Immunofluorescence staining of methanol-fixed HeLa cells showing membrane localization.

HFE (V-14) - sc-18806 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-HFE antibody - ab176123 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human esophagus tissue labelling HFE with ab176123 at 1/100. Magnification: 200x.

Anti-HFE antibody - ab55182 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
ICC/IF image of HFE staining (ab55182) in human blood film. The sections were incubated in 0.3% Triton X with 0.1M PBS to permeabilise the cells and in 10% serum for 30 minutes at RT to block non-specific protein-protein interactions. The sections were then incubated with ab55182 (1:500) for 4 hrs at RT, followed by Alexa 568 conjugated secondary antibody. Red staining of the cell membrane was observed. Macrophages were stained using a CD68 primary and Alexa Fluor 488 conjugated secondary antibody. The nucleus was visualised using Hoechst.See Abreview

Anti-HFE antibody - ab88212 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
ab88212, staining HFE expressing 293 cells (green) by flow cytometry. The black trace is the staining pattern of the negative control (293 cells).

Anti-HFE antibody - ab75401 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-HFE antibody (ab75401) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Nuclear LysateLane 2 : U2OS (Human osteosarcoma cell line) Whole Cell Lysate Lane 3 : A498 (Human Kidney Carcinoma) Whole Cell LysateLysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-HFE antibody - ab102592 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-HFE antibody (ab102592) at 1 µg/ml + HeLa cell lysate at 10 µg

Anti-HFE antibody [EPR6750] - ab170912 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6750
All lanes : Anti-HFE antibody [EPR6750] (ab170912) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : A375 cell lysateLane 3 : A431 cell lysateLysates/proteins at 10 µg per lane.

Anti-HFE antibody [EPR6751(2)] - ab133639 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6751(2)
Lanes 1 - 2 : Anti-HFE antibody [EPR6751(2)] (ab133639) at 1/1000 dilutionLanes 3 - 4 : Rabbit monoclonal anti-myc tagLane 1 : HepG2 whole cell lysate - untransfectedLane 2 : HepG2 whole cell lysate - transfected with pCMV6 human HFE Tag Flag MycLane 3 : HepG2 whole cell lysate - untransfectedLane 4 : HepG2 whole cell lysate - transfected with pCMV6 human HFE Tag Flag MycLysates/proteins at 25 µg per lane.SecondaryHRP-conjugated anti-rabbit IgG polyclonal at 1/10000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-HFE Antibody (aa35-84) - LS-C116261 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
HFE antibody LS-C116261 Western blot of HeLa lysate.

Anti-HFE Antibody (Intracellular Domain, clone EPR6751(2)) - LS-C154468 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6751(2)
Western blot analysis on (A) HeLa, (B) A375, and (C) Caco-2 cell lysates using anti-HFE antibody.

Anti-HFE Antibody - LS-C308227 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-HFE Antibody - LS-C310598 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HFE Antibody (aa12-232) - LS-C311450 from LifeSpan Bioscience

Prices $250.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-HFE Antibody (aa122-148) - LS-C99272 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
HFE Antibody IHC of formalin-fixed and paraffin-embedded human testis tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-HFE Antibody (aa149-198) - LS-C40466 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
HFE antibody LS-C40466 IHC of formalin-fixed, paraffin-embedded human Kidney. Positive label: Epithelial cells of renal tubule indicated with arrows. Antibody concentration 4-8 ug/ml. Magnification 400X.

Anti-HFE Antibody (Ile104) - LS-C177851 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of HLA-H (I104) pAb in extracts from LOVO cells.

Anti-HFE Antibody - LS-C192790 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts of various cell lines, using HFE antibody.

Anti-HFE Antibody - LS-C331410 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded human esophagus using HFE antibody at dilution of 1:100 (200x lens).

Anti-HFE Antibody (clone 1G12) - LS-C197405 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1G12
Immunofluorescence of monoclonal antibody to HFE on HeLa cell. [antibody concentration 10 ug/ml]

Anti-HFE Antibody (clone 3F1) - LS-C169421 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3F1
Immunofluorescence of HepG2 cells using HFE mouse monoclonal antibody (green). Blue: DRAQ5 fluorescent DNA dye.
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