| Gene Symbol |
DPF1
|
| Entrez Gene |
8193
|
| Alt Symbol |
BAF45b, NEUD4, neuro-d4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
D4, zinc and double PHD fingers family 1
|
| Other Description |
BRG1-associated factor 45B|neuro-d4 homolog|zinc finger protein neuro-d4
|
| Swissprots |
Q08AJ0 B3KSY8 Q92782
|
| Accessions |
EAW56760 EAW56761 EAW56762 EAW56763 Q92782 AI857563 AI885717 AK094632 BAG52900 AK127198 AK297581 BAG59970 AK308563 AL529673 AL538568 BC021191 AAH21191 BC125152 AAI25153 BC125153 AAI25154 GQ358728 ACU65923 U43843 AAC50685 XM_005259289 XP_005259346 XM_005259290 XP_005259347 XM_005259292 XP_005259349 XM_006723407 XP_006723470 XM_006723408 XP_006723471 XM_006723409 XP_006723472 XM_006723410 XP_006723473 XM_011527356 XP_011525658 XM_011527357 XP_011525659 XM_011527358 XP_011525660 XR_243964 NM_001135155 NP_001128627 NM_001135156 NP_001128628 NM_001289978 NP_001276907 NM_004647 NP_004638
|
| Function |
May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regula
|
| Subcellular Location |
Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
|
![Western Blot: Neuro D4 Overexpression Lysate (Adult Normal) [NBP2-11099] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Neuro D4.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2338_Neuro%2520D4%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-11099-img0001.jpg)