DPF1
| Gene Symbol | DPF1 |
|---|---|
| Entrez Gene | 8193 |
| Alt Symbol | BAF45b, NEUD4, neuro-d4 |
| Species | Human |
| Gene Type | protein-coding |
| Description | D4, zinc and double PHD fingers family 1 |
| Other Description | BRG1-associated factor 45B|neuro-d4 homolog|zinc finger protein neuro-d4 |
| Swissprots | Q08AJ0 B3KSY8 Q92782 |
| Accessions | EAW56760 EAW56761 EAW56762 EAW56763 Q92782 AI857563 AI885717 AK094632 BAG52900 AK127198 AK297581 BAG59970 AK308563 AL529673 AL538568 BC021191 AAH21191 BC125152 AAI25153 BC125153 AAI25154 GQ358728 ACU65923 U43843 AAC50685 XM_005259289 XP_005259346 XM_005259290 XP_005259347 XM_005259292 XP_005259349 XM_006723407 XP_006723470 XM_006723408 XP_006723471 XM_006723409 XP_006723472 XM_006723410 XP_006723473 XM_011527356 XP_011525658 XM_011527357 XP_011525659 XM_011527358 XP_011525660 XR_243964 NM_001135155 NP_001128627 NM_001135156 NP_001128628 NM_001289978 NP_001276907 NM_004647 NP_004638 |
| Function | May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regula |
| Subcellular Location | Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}. |
DPF1 CRISPR/Cas9 KO Plasmid (h) - sc-409539 from Santa Cruz Biotechnology
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DPF1 HDR Plasmid (h) - sc-409539-HDR from Santa Cruz Biotechnology
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DPF1 Double Nickase Plasmid (h) - sc-409539-NIC from Santa Cruz Biotechnology
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DPF1 Double Nickase Plasmid (h2) - sc-409539-NIC-2 from Santa Cruz Biotechnology
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DPF1 CRISPR Activation Plasmid (h) - sc-409539-ACT from Santa Cruz Biotechnology
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DPF1 CRISPR Activation Plasmid (h2) - sc-409539-ACT-2 from Santa Cruz Biotechnology
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DPF1 Lentiviral Activation Particles (h) - sc-409539-LAC from Santa Cruz Biotechnology
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DPF1 Lentiviral Activation Particles (h2) - sc-409539-LAC-2 from Santa Cruz Biotechnology
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DPF1 siRNA (h) - sc-97084 from Santa Cruz Biotechnology
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DPF1 shRNA Plasmid (h) - sc-97084-SH from Santa Cruz Biotechnology
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DPF1 shRNA (h) Lentiviral Particles - sc-97084-V from Santa Cruz Biotechnology
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Neuro D4 RNAi - H00008193-R01 from Novus Biologicals
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MISSION® esiRNA - EHU151411 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7447 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7447 from Sigma-Aldrich
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DPF1 siRNA (Human) - CRH5392 from Cohesion Biosciences
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DPF1 - MBS828697 from MyBioSource
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shRNA set against Human DPF1 (NM_004647.2) - SHH280521 from Creative biogene
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Human DPF1 siRNA - orb265894 from Biorbyt
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DPF1 shRNA Plasmid (Human) - CHH5392 from Cohesion Biosciences
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DPF1 miRNA 3'UTR clone - MiUTR1H-02962 from Creative biogene
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DPF1 miRNA 3'UTR clone - MiUTR3H-04306 from Creative biogene
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DPF1 miRNA 3'UTR clone - MiUTR3H-04307 from Creative biogene
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