| Gene Symbol |
CD244
|
| Entrez Gene |
51744
|
| Alt Symbol |
2B4, NAIL, NKR2B4, Nmrk, SLAMF4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
CD244 molecule, natural killer cell receptor 2B4
|
| Other Description |
NK cell activation inducing ligand NAIL|NK cell activation-inducing ligand|NK cell type I receptor protein 2B4|SLAM family member 4|h2B4|natural killer cell receptor 2B4|signaling lymphocytic activation molecule 4
|
| Swissprots |
Q9Y288 Q5VYI2 Q5VYI6 Q5VYI7 Q96T47 Q9BZW8 Q9NQD2 Q9NQD3
|
| Accessions |
AAK57926 CAJ33698 EAW52691 EAW52692 EAW52693 EAW52694 Q9BZW8 AF105261 AAD32538 AF107761 AAD37838 AF117711 AAF28833 AF145782 AAD38951 AF242540 AAK00233 AF363452 AAK50015 AJ245375 CAC00647 AJ245376 CAC00648 AJ245377 CAC00649 AK295950 BAG58732 AK313201 BAG36017 BC028073 AAH28073 BC041607 BC053985 AAH53985 HQ448452 ADQ32932 XM_011509620 XP_011507922 XM_011509621 XP_011507923 XM_011509622 XP_011507924 XM_011509623 XP_011507925 NM_001166663 NP_001160135 NM_001166664 NP_001160136 NM_016382 NP_057466
|
| Function |
Modulate other receptor-ligand interactions to enhance leukocyte activation. CD244/2B4 is the only heterophilic receptor of SLAM family. {ECO:0000269|PubMed:10359122}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Expressed in spleen, PBL, followed by lung, liver, testis and small intestine. Expressed not only in NK cells, but also on monocytes and basophils. {ECO:0000269|PubMed:10556801}.
|
| Top Pathways |
Natural killer cell mediated cytotoxicity
|
![Western Blot: CD244 Overexpression Lysate (Adult Normal) [NBL1-08924] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CD244.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5732_CD244%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-08924-img0002.jpg)