| Gene Symbol |
RNF114
|
| Entrez Gene |
55905
|
| Alt Symbol |
PSORS12, ZNF313
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ring finger protein 114
|
| Other Description |
E3 ubiquitin-protein ligase RNF114|zinc finger protein 228|zinc finger protein 313
|
| Swissprots |
Q9Y508 E1P627 Q6N0B0 B2RDQ9 B4DWY5
|
| Accessions |
EAW75641 EAW75642 EAW75643 EAW75644 Q9Y508 AF131742 AF265215 AAF75763 AK091976 AK097265 AK297188 BAG59677 AK301731 BAG63197 AK315638 BAG38006 BC013695 AAH13695 BC066919 AAH66919 BM830132 BT006795 AAP35441 BX640603 CAE45709 HQ447087 ADQ31574 NM_018683 NP_061153
|
| Function |
E3 ubiquitin-protein ligase promoting the ubiquitination and degradation of the CDK inhibitor CDKN1A and probably also CDKN1B and CDKN1C. These activities stimulate cell cycle's G1-to-S phase transition and suppress cellular senescence. May play a role in spermatogenesis. {ECO:0000269|PubMed:23645206}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:23645206}. Nucleus {ECO:0000269|PubMed:23645206}.
|
| Tissue Specificity |
Expressed in numerous tissues, including skin, CD4 lymphocytes and dendritic cells. Highest levels in testis. {ECO:0000269|PubMed:18364390}.
|