Gene Symbol | RNF114 |
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Entrez Gene | 55905 |
Alt Symbol | PSORS12, ZNF313 |
Species | Human |
Gene Type | protein-coding |
Description | ring finger protein 114 |
Other Description | E3 ubiquitin-protein ligase RNF114|zinc finger protein 228|zinc finger protein 313 |
Swissprots | Q9Y508 E1P627 Q6N0B0 B2RDQ9 B4DWY5 |
Accessions | EAW75641 EAW75642 EAW75643 EAW75644 Q9Y508 AF131742 AF265215 AAF75763 AK091976 AK097265 AK297188 BAG59677 AK301731 BAG63197 AK315638 BAG38006 BC013695 AAH13695 BC066919 AAH66919 BM830132 BT006795 AAP35441 BX640603 CAE45709 HQ447087 ADQ31574 NM_018683 NP_061153 |
Function | E3 ubiquitin-protein ligase promoting the ubiquitination and degradation of the CDK inhibitor CDKN1A and probably also CDKN1B and CDKN1C. These activities stimulate cell cycle's G1-to-S phase transition and suppress cellular senescence. May play a role in spermatogenesis. {ECO:0000269|PubMed:23645206}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:23645206}. Nucleus {ECO:0000269|PubMed:23645206}. |
Tissue Specificity | Expressed in numerous tissues, including skin, CD4 lymphocytes and dendritic cells. Highest levels in testis. {ECO:0000269|PubMed:18364390}. |
ZNF313 CRISPR/Cas9 KO Plasmid (h) - sc-405414 from Santa Cruz Biotechnology
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ZNF313 HDR Plasmid (h) - sc-405414-HDR from Santa Cruz Biotechnology
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ZNF313 Double Nickase Plasmid (h) - sc-405414-NIC from Santa Cruz Biotechnology
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ZNF313 Double Nickase Plasmid (h2) - sc-405414-NIC-2 from Santa Cruz Biotechnology
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ZNF313 CRISPR Activation Plasmid (h) - sc-405414-ACT from Santa Cruz Biotechnology
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ZNF313 CRISPR Activation Plasmid (h2) - sc-405414-ACT-2 from Santa Cruz Biotechnology
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ZNF313 Lentiviral Activation Particles (h) - sc-405414-LAC from Santa Cruz Biotechnology
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ZNF313 Lentiviral Activation Particles (h2) - sc-405414-LAC-2 from Santa Cruz Biotechnology
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ZNF313 siRNA (h) - sc-76977 from Santa Cruz Biotechnology
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ZNF313 shRNA Plasmid (h) - sc-76977-SH from Santa Cruz Biotechnology
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ZNF313 shRNA (h) Lentiviral Particles - sc-76977-V from Santa Cruz Biotechnology
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ZNF313 RNAi - H00055905-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN18370 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18370 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10273 from Sigma-Aldrich
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RNF114 siRNA (Human) - CRJ1004 from Cohesion Biosciences
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RNF114 - MBS8223031 from MyBioSource
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shRNA set against Human RNF114 (NM_018683.3) - SHH396580 from Creative biogene
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shRNA set against Human ZNF313(NM_018683.3) - SHR184944 from Creative biogene
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RNF114 shRNA Plasmid (Human) - CHJ1004 from Cohesion Biosciences
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RNF114 miRNA 3'UTR clone - MiUTR1H-11553 from Creative biogene
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