RUVBL1

Gene Symbol	RUVBL1
Entrez Gene	8607
Alt Symbol	ECP54, INO80H, NMP238, PONTIN, Pontin52, RVB1, TIH1, TIP49, TIP49A
Species	Human
Gene Type	protein-coding
Description	RuvB-like AAA ATPase 1
Other Description	49 kDa TATA box-binding protein-interacting protein|49 kDa TBP-interacting protein|54 kDa erythrocyte cytosolic protein|ECP-54|INO80 complex subunit H|NMP 238|RuvB (E coli homolog)-like 1|TAP54-alpha|TATA binding protein interacting protein 49 kDa|TIP60-associated protein 54-alpha|nuclear matrix protein 238|pontin 52|ruvB-like 1
Swissprots	Q53HK5 Q9BSX9 Q1KMR0 Q9Y265 P82276 Q53Y27 B2R5S0 Q53HL7
Accessions	AAM45570 EAW79323 Q9Y265 AB012122 BAA28169 AB451224 BAG70038 AB451347 BAG70161 AF070735 AAC77819 AF099084 AAD04427 AJ010058 CAA08986 AK092163 BAG52489 AK222563 BAD96283 AK222575 BAD96295 AK312290 BAG35217 AW069473 BC002993 AAH02993 BC004503 BC012886 AAH12886 BT007057 AAP35706 DA530328 DQ469310 ABF13334 DQ891448 ABM82374 DQ894627 ABM85553 Y18418 CAB46271 XM_005247841 XP_005247898 XM_011513248 XP_011511550 XM_011513249 XP_011511551 XM_011513250 XP_011511552 XR_924202 NM_003707 NP_003698
Function	May be able to bind plasminogen at cell surface and enhance plasminogen activation.
Subcellular Location	Nucleus matrix. Nucleus, nucleoplasm. Cytoplasm. Membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Mainly localized in the nucleus, associated with nuclear matrix or in the nuclear cytosol, although it is also present in the cytoplasm and associated with the cell membranes. In prophase and prometaphase it is located at the centrosome and the branching microtubule spindles. After mitotic nuclear membrane disintigration it accumulates at the centrosome and sites of tubulin polymerization. As cells pass through metaphase and into telophase it is located close to the centrosome at the early phase of tubulin polymerization. In anaphase it accumulates at the zone of tubule interdigitation. In telophase it is found at polar tubule overlap, and it reappears at the site of chromosomal decondensation in the daughter cells.
Tissue Specificity	Ubiquitously expressed with high expression in heart, skeletal muscle and testis.
Top Pathways	Wnt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

RUVBL1-Over-expression-Lysate - LY10929a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

RUVBL1 overexpression lysate - LY418487 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

RUVBL1 293 Cell Lysate - 408624 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg Species Escherichia coli

Pontin 52 (h2): 293T Lysate - sc-175102 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

RUVBL1 Over-expression Lysate Product - GWB-3373D8 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Human RUVBL1 / RVB1 Insect Cell Lysate (WB positive control) - 14074-H07BL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

RUVBL1 Overexpression Lysate (Native) - NBL1-15631 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Human RUVBL1 Baculovirus-Insect Cells Transfected Lysate (positive control) (denatured) - orb175234 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Panoply™ Human RUVBL1 Knockdown Stable Cell Line - CSC-DC013699 from Creative biogene Category Cell Line Species Human

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