RUVBL1
| Gene Symbol | RUVBL1 |
|---|---|
| Entrez Gene | 8607 |
| Alt Symbol | ECP54, INO80H, NMP238, PONTIN, Pontin52, RVB1, TIH1, TIP49, TIP49A |
| Species | Human |
| Gene Type | protein-coding |
| Description | RuvB-like AAA ATPase 1 |
| Other Description | 49 kDa TATA box-binding protein-interacting protein|49 kDa TBP-interacting protein|54 kDa erythrocyte cytosolic protein|ECP-54|INO80 complex subunit H|NMP 238|RuvB (E coli homolog)-like 1|TAP54-alpha|TATA binding protein interacting protein 49 kDa|TIP60-associated protein 54-alpha|nuclear matrix protein 238|pontin 52|ruvB-like 1 |
| Swissprots | Q53HK5 Q9BSX9 Q1KMR0 Q9Y265 P82276 Q53Y27 B2R5S0 Q53HL7 |
| Accessions | AAM45570 EAW79323 Q9Y265 AB012122 BAA28169 AB451224 BAG70038 AB451347 BAG70161 AF070735 AAC77819 AF099084 AAD04427 AJ010058 CAA08986 AK092163 BAG52489 AK222563 BAD96283 AK222575 BAD96295 AK312290 BAG35217 AW069473 BC002993 AAH02993 BC004503 BC012886 AAH12886 BT007057 AAP35706 DA530328 DQ469310 ABF13334 DQ891448 ABM82374 DQ894627 ABM85553 Y18418 CAB46271 XM_005247841 XP_005247898 XM_011513248 XP_011511550 XM_011513249 XP_011511551 XM_011513250 XP_011511552 XR_924202 NM_003707 NP_003698 |
| Function | May be able to bind plasminogen at cell surface and enhance plasminogen activation. |
| Subcellular Location | Nucleus matrix. Nucleus, nucleoplasm. Cytoplasm. Membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Mainly localized in the nucleus, associated with nuclear matrix or in the nuclear cytosol, although it is also present in the cytoplasm and associated with the cell membranes. In prophase and prometaphase it is located at the centrosome and the branching microtubule spindles. After mitotic nuclear membrane disintigration it accumulates at the centrosome and sites of tubulin polymerization. As cells pass through metaphase and into telophase it is located close to the centrosome at the early phase of tubulin polymerization. In anaphase it accumulates at the zone of tubule interdigitation. In telophase it is found at polar tubule overlap, and it reappears at the site of chromosomal decondensation in the daughter cells. |
| Tissue Specificity | Ubiquitously expressed with high expression in heart, skeletal muscle and testis. |
| Top Pathways | Wnt signaling pathway |
Pontin 52 CRISPR/Cas9 KO Plasmid (h) - sc-402304 from Santa Cruz Biotechnology
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Pontin 52 HDR Plasmid (h) - sc-402304-HDR from Santa Cruz Biotechnology
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Pontin 52 Double Nickase Plasmid (h) - sc-402304-NIC from Santa Cruz Biotechnology
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Pontin 52 Double Nickase Plasmid (h2) - sc-402304-NIC-2 from Santa Cruz Biotechnology
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Pontin 52 CRISPR Activation Plasmid (h) - sc-402304-ACT from Santa Cruz Biotechnology
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Pontin 52 CRISPR Activation Plasmid (h2) - sc-402304-ACT-2 from Santa Cruz Biotechnology
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Pontin 52 Lentiviral Activation Particles (h) - sc-402304-LAC from Santa Cruz Biotechnology
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Pontin 52 Lentiviral Activation Particles (h2) - sc-402304-LAC-2 from Santa Cruz Biotechnology
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Pontin 52 siRNA (h) - sc-43543 from Santa Cruz Biotechnology
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Pontin 52 shRNA Plasmid (h) - sc-43543-SH from Santa Cruz Biotechnology
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Pontin 52 shRNA (h) Lentiviral Particles - sc-43543-V from Santa Cruz Biotechnology
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RUVBL1 RNAi - H00008607-R01 from Novus Biologicals
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MISSION® esiRNA - EHU150721 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18762 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18762 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02379 from Sigma-Aldrich
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RUVBL1 siRNA (Human) - CRH5654 from Cohesion Biosciences
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RUVBL1 - MBS829445 from MyBioSource
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shRNA set against Human RUVB (NM_003707.2) - SHH400828 from Creative biogene
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Human RUVBL1 siRNA - orb266156 from Biorbyt
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RUVBL1 shRNA Plasmid (Human) - CHH5654 from Cohesion Biosciences
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RUVBL1 miRNA 3'UTR clone - MiUTR3H-05979 from Creative biogene
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