SIX3

Gene Symbol	SIX3
Entrez Gene	6496
Alt Symbol	HPE2
Species	Human
Gene Type	protein-coding
Description	SIX homeobox 3
Other Description	homeobox protein SIX3|sine oculis homeobox homolog 3
Swissprots	Q53T42 D6W5A5 O95343
Accessions	AAD11939 AAD15753 AAD51091 AAX93283 AJS11514 EAX00267 EAX00268 O95343 AJ012611 CAB42539 AL162671 CAB83141 BC030289 AAH30289 BC153026 AAI53027 BF569811 BF570321 BM668514 CD673488 EL952320 HG493938 XM_011533042 XP_011531344 NM_005413 NP_005404
Function	Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon. Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression. In addition, Six3 activity is required for the formation of the telencephalon. During postnatal stages of brain development is necessary for ependymal cell maturation by promoting the maturation of radial glia into ependymal cells through regulation of neuroblast proliferation and migration. Acts on the proliferation and differentiation of neural progenitor cells through activating transcription of CCND1 AND CCND2. During early lens formation plays a role in
Subcellular Location	Nucleus {ECO:0000250|UniProtKB:Q62233, ECO:0000255|PROSITE-ProRule:PRU00108}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Six3 (G-7) - sc-398796 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Six3 (A-1) - sc-398797 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Six3 (C-19) - sc-49114 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Six3 (H-59) - sc-134776 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Six3 (J-21) - sc-81985 from Santa Cruz Biotechnology Prices $295.00 Sizes 100 µg/ml Host Mouse Clonality Monoclonal

Anti-Six3 antibody - ab172131 from Abcam Prices $370.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-Six3 antibody - ab139317 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-Six3 antibody - ab124059 from Abcam Prices $359.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Six3 antibody - ab58286 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-SIX3 Antibody (aa230-243) - LS-C55471 from LifeSpan Bioscience Prices $335.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-SIX3 Antibody (aa138-166, AP) - LS-C217530 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SIX3 Antibody (aa138-166, APC) - LS-C217533 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SIX3 Antibody (aa138-166, Biotin) - LS-C217534 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SIX3 Antibody (aa138-166, PE) - LS-C217537 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SIX3 Antibody (aa138-166, Azide-free, HRP) - LS-C217536 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SIX3 Antibody (aa137-166) - LS-C325128 from LifeSpan Bioscience Prices $435.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SIX3 Antibody (aa138-166, FITC) - LS-C217552 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SIX3 Antibody - LS-C340987 from LifeSpan Bioscience Prices $385.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SIX3 + SIX6 Antibody (Asp228) - LS-C176715 from LifeSpan Bioscience Prices $345.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SIX3 Antibody (N-Terminus) - LS-C101388 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-SIX3 Antibody (C-Terminus) - LS-C116055 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-SIX3 Antibody (clone 3D12) - LS-C198201 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 3D12

Anti-SIX3 Antibody (aa138-166) - LS-C161107 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-SIX3 Antibody (Internal) IHC-plus™ - LS-B9336 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Six3 Antibody (2B9) - H00006496-M08 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 2B9

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