SIX3

Gene Symbol	SIX3
Entrez Gene	6496
Alt Symbol	HPE2
Species	Human
Gene Type	protein-coding
Description	SIX homeobox 3
Other Description	homeobox protein SIX3|sine oculis homeobox homolog 3
Swissprots	Q53T42 D6W5A5 O95343
Accessions	AAD11939 AAD15753 AAD51091 AAX93283 AJS11514 EAX00267 EAX00268 O95343 AJ012611 CAB42539 AL162671 CAB83141 BC030289 AAH30289 BC153026 AAI53027 BF569811 BF570321 BM668514 CD673488 EL952320 HG493938 XM_011533042 XP_011531344 NM_005413 NP_005404
Function	Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon. Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression. In addition, Six3 activity is required for the formation of the telencephalon. During postnatal stages of brain development is necessary for ependymal cell maturation by promoting the maturation of radial glia into ependymal cells through regulation of neuroblast proliferation and migration. Acts on the proliferation and differentiation of neural progenitor cells through activating transcription of CCND1 AND CCND2. During early lens formation plays a role in
Subcellular Location	Nucleus {ECO:0000250|UniProtKB:Q62233, ECO:0000255|PROSITE-ProRule:PRU00108}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SIX3 Antibody Blocking Peptide - LS-E3931 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SIX3 Antibody Blocking Peptide - LS-E11326 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SIX3 Antibody Blocking Peptide - LS-E26421 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SIX3 Antibody Blocking Peptide - LS-E13321 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SIX3-Antibody-Center-Blocking-Peptide - BP16129c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SIX3 Blocking Peptide - abx063262 from Abbexa Category Peptide Species Human, Mouse, Rat, Chicken, Zebrafish

SIX3 Blocking Peptide - CBP2068 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Chicken, Zebrafish

Recombinant Human Homeobox protein SIX3(SIX3) - CSB-YP021350HU CSB-EP021350HU CSB-BP021350HU CSB-MP021350HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Six3 (93-200) - sc-4422 WB from Santa Cruz Biotechnology Category Protein Prices $88.00 Sizes 10 µg/0.1 ml Species Human

SIX3, Peptide - MBS659571 from MyBioSource Category Peptide Prices $290.00 Sizes 1 mg Species Human, Rodent

SIX3, Peptide - MBS658818 from MyBioSource Category Peptide Prices $290.00 Sizes 1 mg Species Human, Rodent

SIX3 Peptide, Human - M34GP14278H from Creative Peptides Category Peptide Source Synthetic. Species Human

SIX3 peptide - orb217931 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Zebrafish, Cat

Six3 Recombinant Protein Antigen - NBP2-57249PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Homeobox protein SIX3 (SIX3), Recombinant Protein - MBS1176672 from MyBioSource Category Protein Prices $1,095.00, $1,095.00, $1,325.00, $1,325.00, $1,725.00, $1,725.00, $2,185.00, $2,185.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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