SIX3

Gene Symbol SIX3
Entrez Gene 6496
Alt Symbol HPE2
Species Human
Gene Type protein-coding
Description SIX homeobox 3
Other Description homeobox protein SIX3|sine oculis homeobox homolog 3
Swissprots Q53T42 D6W5A5 O95343
Accessions AAD11939 AAD15753 AAD51091 AAX93283 AJS11514 EAX00267 EAX00268 O95343 AJ012611 CAB42539 AL162671 CAB83141 BC030289 AAH30289 BC153026 AAI53027 BF569811 BF570321 BM668514 CD673488 EL952320 HG493938 XM_011533042 XP_011531344 NM_005413 NP_005404
Function Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon. Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression. In addition, Six3 activity is required for the formation of the telencephalon. During postnatal stages of brain development is necessary for ependymal cell maturation by promoting the maturation of radial glia into ependymal cells through regulation of neuroblast proliferation and migration. Acts on the proliferation and differentiation of neural progenitor cells through activating transcription of CCND1 AND CCND2. During early lens formation plays a role in
Subcellular Location Nucleus {ECO:0000250|UniProtKB:Q62233, ECO:0000255|PROSITE-ProRule:PRU00108}.

Six3 CRISPR/Cas9 KO Plasmid (h) - sc-404026 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Six3 HDR Plasmid (h) - sc-404026-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Six3 Double Nickase Plasmid (h) - sc-404026-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Six3 Double Nickase Plasmid (h2) - sc-404026-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Six3 CRISPR Activation Plasmid (h) - sc-404026-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Six3 CRISPR Activation Plasmid (h2) - sc-404026-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Six3 Lentiviral Activation Particles (h) - sc-404026-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Six3 Lentiviral Activation Particles (h2) - sc-404026-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Six3 siRNA (h) - sc-38788 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Six3 shRNA Plasmid (h) - sc-38788-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Six3 shRNA (h) Lentiviral Particles - sc-38788-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Six3 RNAi - H00006496-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN19369 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19369 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

SIX3 siRNA (Human) - CRH4392 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SIX3 - MBS8219704 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human Six3 (NM_005413.3) - SHH407860 from Creative biogene

Category siRNA
Species Reactivities Human

Human SIX3 siRNA - orb264894 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SIX3 shRNA Plasmid (Human) - CHH4392 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SIX3 miRNA 3'UTR clone - MiUTR4H-TG12451 from Creative biogene

Species Reactivities Human
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