| Gene Symbol |
SIX3
|
| Entrez Gene |
6496
|
| Alt Symbol |
HPE2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SIX homeobox 3
|
| Other Description |
homeobox protein SIX3|sine oculis homeobox homolog 3
|
| Swissprots |
Q53T42 D6W5A5 O95343
|
| Accessions |
AAD11939 AAD15753 AAD51091 AAX93283 AJS11514 EAX00267 EAX00268 O95343 AJ012611 CAB42539 AL162671 CAB83141 BC030289 AAH30289 BC153026 AAI53027 BF569811 BF570321 BM668514 CD673488 EL952320 HG493938 XM_011533042 XP_011531344 NM_005413 NP_005404
|
| Function |
Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon. Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression. In addition, Six3 activity is required for the formation of the telencephalon. During postnatal stages of brain development is necessary for ependymal cell maturation by promoting the maturation of radial glia into ependymal cells through regulation of neuroblast proliferation and migration. Acts on the proliferation and differentiation of neural progenitor cells through activating transcription of CCND1 AND CCND2. During early lens formation plays a role in
|
| Subcellular Location |
Nucleus {ECO:0000250|UniProtKB:Q62233, ECO:0000255|PROSITE-ProRule:PRU00108}.
|