| Gene Symbol |
POLE3
|
| Entrez Gene |
54107
|
| Alt Symbol |
CHARAC17, CHRAC17, YBL1, p17
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
polymerase (DNA directed), epsilon 3, accessory subunit
|
| Other Description |
CHRAC-17|DNA polymerase II subunit 3|DNA polymerase epsilon p17 subunit|DNA polymerase epsilon subunit 3|DNA polymerase epsilon subunit p17|arsenic transactivated protein|arsenic-transactivated protein|asTP|chromatin accessibility complex 17 kDa protein|histone fold protein CHRAC17|huCHRAC17|polymerase (DNA directed), epsilon 3 (p17 subunit)
|
| Swissprots |
Q9NR32 Q8NCE5 Q9NRF9 Q8N758 Q5W0U1
|
| Accessions |
AAF90133 AAY57326 CAF86695 CAF86796 EAW87381 EAW87382 Q9NRF9 AF070640 AF226077 AAF72417 AK074629 BAC11099 AK074762 BAC11190 AK074782 BAC11206 AK092840 AK096050 AY720898 AAU15052 BC003166 AAH03166 BC004170 AAH04170 DA477404 DA521953 DA908447 JF432738 ADZ15955 NM_001278255 NP_001265184 NM_017443 NP_059139 NR_027261
|
| Function |
Forms a complex with DNA polymerase epsilon subunit CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1.
|
| Subcellular Location |
Nucleus {ECO:0000305}.
|
| Tissue Specificity |
Expressed in all tissues tested, including, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
|
| Top Pathways |
DNA replication, Base excision repair, Nucleotide excision repair, HTLV-I infection, Purine metabolism
|