Gene Symbol | POLE3 |
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Entrez Gene | 54107 |
Alt Symbol | CHARAC17, CHRAC17, YBL1, p17 |
Species | Human |
Gene Type | protein-coding |
Description | polymerase (DNA directed), epsilon 3, accessory subunit |
Other Description | CHRAC-17|DNA polymerase II subunit 3|DNA polymerase epsilon p17 subunit|DNA polymerase epsilon subunit 3|DNA polymerase epsilon subunit p17|arsenic transactivated protein|arsenic-transactivated protein|asTP|chromatin accessibility complex 17 kDa protein|histone fold protein CHRAC17|huCHRAC17|polymerase (DNA directed), epsilon 3 (p17 subunit) |
Swissprots | Q9NR32 Q8NCE5 Q9NRF9 Q8N758 Q5W0U1 |
Accessions | AAF90133 AAY57326 CAF86695 CAF86796 EAW87381 EAW87382 Q9NRF9 AF070640 AF226077 AAF72417 AK074629 BAC11099 AK074762 BAC11190 AK074782 BAC11206 AK092840 AK096050 AY720898 AAU15052 BC003166 AAH03166 BC004170 AAH04170 DA477404 DA521953 DA908447 JF432738 ADZ15955 NM_001278255 NP_001265184 NM_017443 NP_059139 NR_027261 |
Function | Forms a complex with DNA polymerase epsilon subunit CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1. |
Subcellular Location | Nucleus {ECO:0000305}. |
Tissue Specificity | Expressed in all tissues tested, including, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. |
Top Pathways | DNA replication, Base excision repair, Nucleotide excision repair, HTLV-I infection, Purine metabolism |
CHRAC17 (D-1) - sc-393397 from Santa Cruz Biotechnology
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CHRAC17 (E-11) - sc-376242 from Santa Cruz Biotechnology
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CHRAC17 (F-19) - sc-13465 from Santa Cruz Biotechnology
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CHRAC17 (N-15) - sc-13463 from Santa Cruz Biotechnology
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Anti-DNA Polymerase epsilon antibody - ab88521 from Abcam
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Anti-POLE3 / DNA Polymerase Epsilon Antibody (aa5-34) - LS-C100903 from LifeSpan Bioscience
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Anti-POLE3 / DNA Polymerase Epsilon Antibody (aa97-147) - LS-C286497 from LifeSpan Bioscience
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Anti-CHRAC17 / POLE3 Antibody (aa97-147) - LS-C92026 from LifeSpan Bioscience
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Anti-POLE3 / DNA Polymerase Epsilon Antibody (clone 3C5.1, Biotin) - LS-C140794 from LifeSpan Bioscience
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Anti-POLE3 / DNA Polymerase Epsilon Antibody (clone 3C5.1, DY650) - LS-C140795 from LifeSpan Bioscience
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Anti-CHRAC17 / POLE3 Antibody (clone 3C5.1, HRP) - LS-C140797 from LifeSpan Bioscience
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Anti-POLE3 / DNA Polymerase Epsilon Antibody (clone 3C5.1, DY550) - LS-C140798 from LifeSpan Bioscience
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Anti-POLE3 / DNA Polymerase Epsilon Antibody (clone 3C5.1, DY488) - LS-C140796 from LifeSpan Bioscience
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Anti-POLE3 / DNA Polymerase Epsilon Antibody (N-Terminus) - LS-C30573 from LifeSpan Bioscience
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Anti-POLE3 / DNA Polymerase Epsilon Antibody (N-Terminus) - LS-C102743 from LifeSpan Bioscience
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Anti-POLE3 / DNA Polymerase Epsilon Antibody (clone 3C5.1) - LS-C2650 from LifeSpan Bioscience
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Anti-POLE3 / DNA Polymerase Epsilon Antibody - LS-C335676 from LifeSpan Bioscience
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Anti-POLE3 / DNA Polymerase Epsilon Antibody (aa97-147) - LS-C288056 from LifeSpan Bioscience
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Anti-POLE3 / DNA Polymerase Epsilon Antibody (C-Terminus) - LS-C146393 from LifeSpan Bioscience
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DNA Polymerase epsilon catalytic subunit A Antibody (3C5.1) - NB100-115 from Novus Biologicals
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DNA Polymerase epsilon subunit 3 Antibody - NB100-60438 from Novus Biologicals
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DNA Polymerase epsilon subunit 3 Antibody - H00054107-B02 from Novus Biologicals
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DNA Polymerase epsilon subunit 3 Antibody - H00054107-B02P from Novus Biologicals
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DNA Polymerase epsilon subunit 3 Antibody - H00054107-B01 from Novus Biologicals
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DNA Polymerase epsilon subunit 3 Antibody - H00054107-A01 from Novus Biologicals
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