VEGFC

Gene Symbol	VEGFC
Entrez Gene	7424
Alt Symbol	Flt4-L, LMPH1D, VRP
Species	Human
Gene Type	protein-coding
Description	vascular endothelial growth factor C
Other Description	FLT4 ligand DHM\|vascular endothelial growth factor-related protein
Swissprots	B2R9Q8 P49767
Accessions	AAB82540 CAH23418 CAI59112 CAI63838 CAI84578 CAJ29667 CAJ32890 CAJ32903 CAL32724 CAV32970 CBH30535 EAX04717 P49767 AK313879 BAG36605 AW294939 BC035212 AAH35212 BC063685 AAH63685 BF528469 CR541897 CAG46695 DA044965 DQ891162 ABM82088 DQ893345 ABM84271 DQ894481 ABM85407 DQ896666 ABM87665 U43142 AAA85214 U58111 AAB02909 X94216 CAA63907 NM_005429 NP_005420
Function	Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors. {ECO:0000269\|PubMed:20145116}.
Subcellular Location	Secreted.
Tissue Specificity	Spleen, lymph node, thymus, appendix, bone marrow, heart, placenta, ovary, skeletal muscle, prostate, testis, colon and small intestine and fetal liver, lung and kidney, but not in peripheral blood lymphocyte.
Top Pathways	Cytokine-cytokine receptor interaction, Focal adhesion, PI3K-Akt signaling pathway, TNF signaling pathway, Rap1 signaling pathway

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