Gene Symbol | VEGFC |
---|---|
Entrez Gene | 7424 |
Alt Symbol | Flt4-L, LMPH1D, VRP |
Species | Human |
Gene Type | protein-coding |
Description | vascular endothelial growth factor C |
Other Description | FLT4 ligand DHM|vascular endothelial growth factor-related protein |
Swissprots | B2R9Q8 P49767 |
Accessions | AAB82540 CAH23418 CAI59112 CAI63838 CAI84578 CAJ29667 CAJ32890 CAJ32903 CAL32724 CAV32970 CBH30535 EAX04717 P49767 AK313879 BAG36605 AW294939 BC035212 AAH35212 BC063685 AAH63685 BF528469 CR541897 CAG46695 DA044965 DQ891162 ABM82088 DQ893345 ABM84271 DQ894481 ABM85407 DQ896666 ABM87665 U43142 AAA85214 U58111 AAB02909 X94216 CAA63907 NM_005429 NP_005420 |
Function | Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors. {ECO:0000269|PubMed:20145116}. |
Subcellular Location | Secreted. |
Tissue Specificity | Spleen, lymph node, thymus, appendix, bone marrow, heart, placenta, ovary, skeletal muscle, prostate, testis, colon and small intestine and fetal liver, lung and kidney, but not in peripheral blood lymphocyte. |
Top Pathways | Cytokine-cytokine receptor interaction, Focal adhesion, PI3K-Akt signaling pathway, TNF signaling pathway, Rap1 signaling pathway |
VEGF-C CRISPR/Cas9 KO Plasmid (h) - sc-400553 from Santa Cruz Biotechnology
|
||||||||
VEGF-C HDR Plasmid (h) - sc-400553-HDR from Santa Cruz Biotechnology
|
||||||||
VEGF-C Double Nickase Plasmid (h) - sc-400553-NIC from Santa Cruz Biotechnology
|
||||||||
VEGF-C Double Nickase Plasmid (h2) - sc-400553-NIC-2 from Santa Cruz Biotechnology
|
||||||||
VEGF-C CRISPR Activation Plasmid (h) - sc-400553-ACT from Santa Cruz Biotechnology
|
||||||||
VEGF-C CRISPR Activation Plasmid (h2) - sc-400553-ACT-2 from Santa Cruz Biotechnology
|
||||||||
VEGF-C Lentiviral Activation Particles (h) - sc-400553-LAC from Santa Cruz Biotechnology
|
||||||||
VEGF-C Lentiviral Activation Particles (h2) - sc-400553-LAC-2 from Santa Cruz Biotechnology
|
||||||||
VEGF-C siRNA (h) - sc-39842 from Santa Cruz Biotechnology
|
||||||||
VEGF-C shRNA Plasmid (h) - sc-39842-SH from Santa Cruz Biotechnology
|
||||||||
VEGF-C shRNA (h) Lentiviral Particles - sc-39842-V from Santa Cruz Biotechnology
|
||||||||
VEGF-C RNAi - H00007424-R01 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU013781 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN1077 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1077 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR03588 from Sigma-Aldrich
|
||||||||
VEGFC siRNA (Human) - CRH5080 from Cohesion Biosciences
|
||||||||
VEGFC - MBS8210802 from MyBioSource
|
||||||||
Human VEGFC siRNA - orb265582 from Biorbyt
|
||||||||
VEGFC shRNA Plasmid (Human) - CHH5080 from Cohesion Biosciences
|