| Gene Symbol | FCGR3A |
|---|---|
| Entrez Gene | 2214 |
| Alt Symbol | CD16, CD16A, FCG3, FCGR3, FCGRIII, FCR-10, FCRIII, FCRIIIA, IGFR3, IMD20 |
| Species | Human |
| Gene Type | protein-coding |
| Description | Fc fragment of IgG, low affinity IIIa, receptor (CD16a) |
| Other Description | CD16a antigen|Fc fragment of IgG, low affinity III, receptor for (CD16)|Fc gamma receptor III-A|Fc-gamma RIII-alpha|Fc-gamma RIIIa|Fc-gamma receptor III-2 (CD 16)|Fc-gamma receptor IIIb (CD16)|FcgammaRIIIA|fc-gamma RIII|igG Fc receptor III-2|immunoglobulin G Fc receptor III|low affinity immunoglobulin gamma Fc region receptor III-A|neutrophil-specific antigen NA |
| Swissprots | Q53FL6 A2N6W9 P08637 Q6PIJ0 Q65ZM6 Q53FJ0 Q5EBR4 |
| Accessions | AAD48438 ACS66838 ACS66839 ACS66840 ACS66841 ACS66842 ACS66843 ACS66844 ACS66845 BAA86888 CAA86295 CBL93996 P08637 AK223268 BAD96988 AK223295 BAD97015 AK302126 BAG63503 BC017865 AAH17865 BC033678 AAH33678 BC036723 AAH36723 BI768140 DA674960 DA933259 DA944383 DA957430 HQ447137 ADQ31624 M24853 AAA53506 S62490 S76824 AAB33925 X52645 CAA36870 XM_011509293 XP_011507595 NM_000569 NP_000560 NM_001127592 NP_001121064 NM_001127593 NP_001121065 NM_001127595 NP_001121067 NM_001127596 NP_001121068 |
| Function | Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis. {ECO:0000269|PubMed:21768335, ECO:0000269|PubMed:22023369}. |
| Subcellular Location | Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Secreted. Note=Exists also as a soluble receptor. |
| Tissue Specificity | Expressed on natural killer cells, macrophages, subpopulation of T-cells, immature thymocytes and placental trophoblasts. |
| Top Pathways | Natural killer cell mediated cytotoxicity, Systemic lupus erythematosus, Fc gamma R-mediated phagocytosis, Leishmaniasis, Phagosome |