Gene Symbol | PRAME |
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Entrez Gene | 23532 |
Alt Symbol | CT130, MAPE, OIP-4, OIP4 |
Species | Human |
Gene Type | protein-coding |
Description | preferentially expressed antigen in melanoma |
Other Description | Opa-interacting protein OIP4|cancer/testis antigen 130|melanoma antigen preferentially expressed in tumors|opa-interacting protein 4|preferentially expressed antigen of melanoma |
Swissprots | O43481 B2R6Y7 Q8IXN8 P78395 |
Accessions | EAW59518 EAW59519 EAW59520 EAW59521 EAW59522 EAW59523 P78395 AF025440 AAC39560 AI613210 AK129783 AK302188 BAH13644 AK304593 BAH14222 AK312769 BAG35634 AK316395 BAH14766 BC014074 AAH14074 BC022008 AAH22008 BC039731 AAH39731 BM015464 BQ432004 BU151249 CF121110 CR456549 CAG30435 CU013149 CAK54580 CU013437 CAK54879 DB024053 DC395455 DQ893473 ABM84399 DQ896327 ABM87326 JQ511981 AFX65483 JQ511982 AFX65484 JQ511983 AFX65485 JQ511984 AFX65486 JQ511985 AFX65487 U65011 AAC51160 XM_011530034 XP_011528336 XM_011530035 XP_011528337 XM_011546897 XP_011545199 XM_011546898 XP_011545200 NM_001291715 NP_001278644 NM_001291716 NP_001278645 NM_001291717 NP_001278646 NM_001291719 NP_001278648 NM_006115 NP_006106 NM_206953 NP_996836 NM_206954 NP_996837 NM_206955 NP_996838 NM_206956 NP_996839 |
Function | Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis. {ECO:0000269|PubMed:16179254}. |
Subcellular Location | Nucleus {ECO:0000305|PubMed:16620968}. Cell membrane {ECO:0000269|PubMed:16620968}. |
Tissue Specificity | Expressed in testis. Detected in samples of kidney, brain and skin. {ECO:0000269|PubMed:9047241}. |
PRAME-Over-expression-Lysate - LY11575a from Abgent, a WuXi AppTec company
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PRAME 293T Cell Transient Overexpression Lysate(Denatured) - H00023532-T01 from Acris Antibodies
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PRAME 293 Cell Lysate - 401647 from ABBIOTEC
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PRAME 293 Cell Lysate - 403293 from ABBIOTEC
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PRAME 293 Cell Lysate - 403292 from ABBIOTEC
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PRAME Overexpression Lysate (Native) - NBL1-14723 from Novus Biologicals
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PRAME Overexpression Lysate (Denatured) - H00023532-T01 from Novus Biologicals
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PRAME Overexpression Lysate (Native) - NBL1-14724 from Novus Biologicals
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PRAME Overexpression Lysate (Native) - NBL1-14725 from Novus Biologicals
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PRAME (h): 293T Lysate - sc-115478 from Santa Cruz Biotechnology
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PRAME (h2): 293T Lysate - sc-129538 from Santa Cruz Biotechnology
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PRAME (h3): 293T Lysate - sc-129539 from Santa Cruz Biotechnology
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PRAME (h4): 293T Lysate - sc-159893 from Santa Cruz Biotechnology
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PRAME Over-expression Lysate Product - GWB-D8CE85 from Genway Biotech
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PRAME Over-expression Lysate Product - GWB-B363FD from Genway Biotech
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PRAME Over-expression Lysate Product - GWB-77DAD2 from Genway Biotech
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PRAME Overexpression Lysate (Native) - NBP2-04526 from Novus Biologicals
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PRAME Overexpression Lysate (Native) - NBP2-04525 from Novus Biologicals
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PRAME Overexpression Lysate (Native) - NBP2-10128 from Novus Biologicals
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PRAME Overexpression Lysate (Native) - NBP2-10127 from Novus Biologicals
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PRAME Overexpression Lysate (Denatured) - H00023532-T02 from Novus Biologicals
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Panoply™ Human PRAME Knockdown Stable Cell Line - CSC-DC012314 from Creative biogene
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