DOC2A

Gene Symbol DOC2A
Entrez Gene 8448
Alt Symbol Doc2
Species Human
Gene Type protein-coding
Description double C2-like domains, alpha
Other Description doc2-alpha|double C2-like domain-containing protein alpha
Swissprots Q7Z5G0 Q8IVX0 Q6P4G4 B4DEJ2 Q14183 H3BNH6
Accessions EAW79942 EAW79943 EAW79944 EAW79945 EAW79946 EAW79947 EAW79948 EAW79949 EAW79950 EAW79951 EAW79952 Q14183 AK090829 AK293651 BAG57103 AK309158 BC041769 AAH41769 BC055284 AAH55284 BC063436 AAH63436 BI757951 BX460259 D31897 BAA06695 DC399462 XM_005255635 XP_005255692 XM_006721099 XP_006721162 XM_011545972 XP_011544274 XM_011545973 XP_011544275 XM_011545974 XP_011544276 XM_011545975 XP_011544277 NM_001282062 NP_001268991 NM_001282063 NP_001268992 NM_001282068 NP_001268997 NM_003586 NP_003577 NR_104089 NR_104090
Function Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. {ECO:0000269|PubMed:18354201, ECO:0000269|PubMed:9736751, ECO:0000269|PubMed:9804756}.
Subcellular Location Lysosome {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Cell junction, synapse, synaptosome. Note=Colocalizes to synaptic vesicles.
Tissue Specificity Predominantly expressed in brain. Also expressed in testis. {ECO:0000269|PubMed:7826360, ECO:0000269|PubMed:8554557}.

DOC2A (L-14) - sc-160302 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-DOC2A antibody - ab171308 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-DOC2A antibody (ab171308) + K562 cell lysate at 35 µg

Anti-DOC2A antibody - ab155168 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-DOC2A antibody (ab155168) at 1/1000 dilution + Mouse brain whole cell lysate at 50 µg

Anti-DOC2A antibody - ab126838 from Abcam

Prices $242.00
Sizes 200 µl
Host Goat
Clonality Polyclonal

Anti-DOC2A antibody - ab130977 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-DOC2A antibody (ab130977) at 1 µg/ml + Human placenta lysate at 10 µg

Anti-DOC2A Antibody - LS-C125479 from LifeSpan Bioscience

Prices $425.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

Anti-DOC2A Antibody (aa107-156) - LS-C151802 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
DOC2A antibody Western Blot of Placenta.

Anti-DOC2A Antibody (aa277-306, APC) - LS-C256250 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DOC2A Antibody (aa277-306, Biotin) - LS-C259203 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DOC2A Antibody (aa277-306, AP) - LS-C256246 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DOC2A Antibody (aa277-306, FITC) - LS-C259204 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DOC2A Antibody (aa277-306, Azide-free, HRP) - LS-C259205 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DOC2A Antibody (aa277-306, PE) - LS-C259206 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DOC2A Antibody (aa284-314) - LS-C320926 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DOC2A Antibody (clone 3C11) - LS-C198563 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3C11
Detection limit for recombinant GST tagged DOC2A is 1 ng/ml as a capture antibody.

Anti-DOC2A Antibody (aa277-306) - LS-C167499 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
DOC2A Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human brain tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-DOC2A Antibody (aa233-246) IHC-plus™ - LS-B10339 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-DOC2A antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10339 concentration 5 ug/ml.

Doc2-alpha Antibody - AF7904 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Sheep
Clonality Polyclonal

Doc2-alpha Antibody (842213) - MAB7904 from Novus Biologicals

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 842213
Doc2 alpha was detected in immersion fixed paraffin-embedded sections of human brain (hippocampus) using Mouse Anti-Human Doc2 alpha Monoclonal Antibody (Catalog # MAB7904) at 15 µg/mL overnight at 4 °C. Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (Catalog # CTS013). Tissue was stained using the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). Specific staining was localized to cytoplasm of neurons. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.

Doc2-alpha Antibody - NBP2-16209 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Doc2-alpha Antibody [NBP2-16209] - Sample (50 ug of whole cell lysate) A: Mouse Brain, 10% SDS PAGE gel, diluted at 1:1000.

Doc2-alpha Antibody - NBP1-98544 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal

Doc2-alpha Antibody - H00008448-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

Doc2-alpha Antibody (3C11) - H00008448-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3C11

Anti-DOC2A antibody produced in rabbit - SAB2700588 from Sigma-Aldrich

Prices $326.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-DOC2A: <B>Cat. No. SAB2700588</B>: Western Blot analysis of DOC2A in extracts from <B>Lanes</B><BR/>A. Mouse brain using <B>Cat. No. SAB2700588</B> at a 1:1000 dilution.

Monoclonal Anti-DOC2A antibody produced in mouse - WH0008448M1 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3C11
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