| Gene Symbol |
DOC2A
|
| Entrez Gene |
8448
|
| Alt Symbol |
Doc2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
double C2-like domains, alpha
|
| Other Description |
doc2-alpha|double C2-like domain-containing protein alpha
|
| Swissprots |
Q7Z5G0 Q8IVX0 Q6P4G4 B4DEJ2 Q14183 H3BNH6
|
| Accessions |
EAW79942 EAW79943 EAW79944 EAW79945 EAW79946 EAW79947 EAW79948 EAW79949 EAW79950 EAW79951 EAW79952 Q14183 AK090829 AK293651 BAG57103 AK309158 BC041769 AAH41769 BC055284 AAH55284 BC063436 AAH63436 BI757951 BX460259 D31897 BAA06695 DC399462 XM_005255635 XP_005255692 XM_006721099 XP_006721162 XM_011545972 XP_011544274 XM_011545973 XP_011544275 XM_011545974 XP_011544276 XM_011545975 XP_011544277 NM_001282062 NP_001268991 NM_001282063 NP_001268992 NM_001282068 NP_001268997 NM_003586 NP_003577 NR_104089 NR_104090
|
| Function |
Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. {ECO:0000269|PubMed:18354201, ECO:0000269|PubMed:9736751, ECO:0000269|PubMed:9804756}.
|
| Subcellular Location |
Lysosome {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Cell junction, synapse, synaptosome. Note=Colocalizes to synaptic vesicles.
|
| Tissue Specificity |
Predominantly expressed in brain. Also expressed in testis. {ECO:0000269|PubMed:7826360, ECO:0000269|PubMed:8554557}.
|