DOC2A

Gene Symbol DOC2A
Entrez Gene 8448
Alt Symbol Doc2
Species Human
Gene Type protein-coding
Description double C2-like domains, alpha
Other Description doc2-alpha|double C2-like domain-containing protein alpha
Swissprots Q7Z5G0 Q8IVX0 Q6P4G4 B4DEJ2 Q14183 H3BNH6
Accessions EAW79942 EAW79943 EAW79944 EAW79945 EAW79946 EAW79947 EAW79948 EAW79949 EAW79950 EAW79951 EAW79952 Q14183 AK090829 AK293651 BAG57103 AK309158 BC041769 AAH41769 BC055284 AAH55284 BC063436 AAH63436 BI757951 BX460259 D31897 BAA06695 DC399462 XM_005255635 XP_005255692 XM_006721099 XP_006721162 XM_011545972 XP_011544274 XM_011545973 XP_011544275 XM_011545974 XP_011544276 XM_011545975 XP_011544277 NM_001282062 NP_001268991 NM_001282063 NP_001268992 NM_001282068 NP_001268997 NM_003586 NP_003577 NR_104089 NR_104090
Function Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. {ECO:0000269|PubMed:18354201, ECO:0000269|PubMed:9736751, ECO:0000269|PubMed:9804756}.
Subcellular Location Lysosome {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Cell junction, synapse, synaptosome. Note=Colocalizes to synaptic vesicles.
Tissue Specificity Predominantly expressed in brain. Also expressed in testis. {ECO:0000269|PubMed:7826360, ECO:0000269|PubMed:8554557}.

DOC2A CRISPR/Cas9 KO Plasmid (h) - sc-411177 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DOC2A HDR Plasmid (h) - sc-411177-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DOC2A Double Nickase Plasmid (h) - sc-411177-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DOC2A Double Nickase Plasmid (h2) - sc-411177-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DOC2A CRISPR Activation Plasmid (h) - sc-411177-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DOC2A CRISPR Activation Plasmid (h2) - sc-411177-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DOC2A Lentiviral Activation Particles (h) - sc-411177-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DOC2A Lentiviral Activation Particles (h2) - sc-411177-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DOC2A siRNA (h) - sc-93040 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

DOC2A shRNA Plasmid (h) - sc-93040-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

DOC2A shRNA (h) Lentiviral Particles - sc-93040-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Doc2-alpha RNAi - H00008448-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU087791 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN7412 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7412 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR06111 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr06111

DOC2A siRNA (Human) - CRH5536 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

DOC2A - MBS8230632 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human DOC2A (NM_003586.2) - SHH280097 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human DOC2A(NM_003586.2) - SHH012959 from Creative biogene

Category siRNA
Species Reactivities Human

Human DOC2A siRNA - orb266038 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

DOC2A shRNA Plasmid (Human) - CHH5536 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

DOC2A miRNA 3'UTR clone - MiUTR1H-02949 from Creative biogene

Species Reactivities Human
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