HTR1B

Gene Symbol	HTR1B
Entrez Gene	3351
Alt Symbol	5-HT1B, 5-HT1DB, HTR1D2, HTR1DB, S12
Species	Human
Gene Type	protein-coding
Description	5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
Other Description	5-HT-1B|5-HT-1D-beta|5-hydroxytryptamine receptor 1B|serotonin 1D beta receptor|serotonin receptor 1B
Swissprots	Q4VAY7 P28222
Accessions	AAA36029 AAA36030 AAA58675 AAO67712 BAA01763 BAA94455 EAW48722 P28222 AK290080 BAF82769 AK315325 BAG37726 BC069065 AAH69065 BC096206 AAH96206 BC096207 AAH96207 BC096208 AAH96208 KJ534870 AHW56510 M81590 AAA60316 NM_000863 NP_000854
Function	G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries. {ECO:0000269|PubMed:10452531, ECO:0000269|PubMed:1315531, ECO:0000269|PubMed:1328844, ECO:0000269|PubMed:1348246, ECO:0000269|PubMed:1351684, E
Subcellular Location	Cell membrane {ECO:0000269|PubMed:10452531, ECO:0000269|PubMed:1315531, ECO:0000269|PubMed:1328844, ECO:0000269|PubMed:1348246, ECO:0000269|PubMed:1351684, ECO:0000269|PubMed:1559993, ECO:0000269|PubMed:1565658, ECO:0000269|PubMed:1610347, ECO:0000269|PubMed:23519210, ECO:0000269|PubMed:23519215}; Multi-pass membrane protein {ECO:0000269|PubMed:10452531, ECO:0000269|PubMed:1315531, ECO:0000269|PubMed:1328844, ECO:0000269|PubMed:1348246, ECO:0000269|PubMed:1351684, ECO:0000269|PubMed:1559993, ECO:0000269|PubMed:1565658, ECO:0000269|PubMed:1610347, ECO:0000269|PubMed:23519210, ECO:0000269|PubMed:23519215}.
Tissue Specificity	Detected in cerebral artery smooth muscle cells (at protein level). Detected in brain cortex, striatum, amygdala, medulla, hippocampus, caudate nucleus and putamen. {ECO:0000269|PubMed:1348246, ECO:0000269|PubMed:1351684, ECO:0000269|PubMed:15853772}.
Top Pathways	cAMP signaling pathway, Neuroactive ligand-receptor interaction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human HTR1B / 5-HT1B Receptor ELISA Kit (Sandwich ELISA) - LS-F10686 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 78 Range 78-5000 pg/ml

5-hydroxytryptamine receptor 1B, HTR1B, Human, ELISA Kit - E10279h from ARP American Research Products Category ELISA Kit Prices $736.00 Sizes 96 t Range 78-5000 pg/mL

5-hydroxytryptamine (serotonin) receptor 1B, ELISA Kit - MBS9325913 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

5-hydroxytryptamine receptor 1B, ELISA Kit - MBS283197 from MyBioSource Category ELISA Kit Prices $465.00, $790.00, $3,500.00, $6,655.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

5-hydroxytryptamine receptor 1B, ELISA Kit - MBS283499 from MyBioSource Category ELISA Kit Prices $425.00, $720.00, $3,160.00, $6,055.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

5-hydroxytryptamine receptor 1B , ELISA Kit - MBS280537 from MyBioSource Category ELISA Kit Prices $465.00, $790.00, $3,500.00, $6,655.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Rat HTR1B / 5-HT1B Receptor ELISA Kit (Custom ELISA) - LS-F15673 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 78-5000 pg/ml

Rabbit HTR1B / 5-HT1B Receptor ELISA Kit - LS-F15674 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range To be determined

Dog HTR1B / 5-HT1B Receptor ELISA Kit (Custom ELISA) - LS-F15672 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 78-5000 pg/ml

Pig HTR1B / 5-HT1B Receptor ELISA Kit (Custom ELISA) - LS-F15671 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 78-5000 pg/ml

Mouse HTR1B / 5-HT1B Receptor ELISA Kit (Custom ELISA) - LS-F15675 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 78-5000 pg/ml

Human 5-hydroxytryptamine receptor 1B ELISA Kit - abx250403 from Abbexa Category ELISA Kit Range 78 pg/ml - 5000 pg/ml

Human 5-hydroxytryptamine receptor 1B ELISA Kit - EKE54604 from Biomatik Category ELISA Kit Prices $809.60, $3,440.80, $6,476.80 Sizes 96 t, 5x96t, 10x96t Sensitivity The minimum detectable dose of this kit is typically less than 34 pg/mL Range 78-5000 pg/mL

HTR1B - EKH2304 from Nordic BioSite Sensitivity 46.9pg/ml Range 78-5000pg/ml

HTR1B ELISA Kit (Human) : 96 Wells (OKEH02074) - OKEH02074 from Aviva Systems Biology Category ELISA Kit Prices $480.00 Sizes 96 wells Sensitivity < 34 pg/mL Range 78 - 5000 pg/mL

Human HTR1B ELISA Kit - E042079 from Biobool Category ELISA Kit Sensitivity <46.9pg/ml

Human 5-hydroxytryptamine receptor 1B ELISA Kit - EK2582 from Signalway Antibody Category ELISA Kit Prices $739.00 Sizes 1x96t Sensitivity less than 34pg/mL Range 78-5000 pg/mL

anti-Serotonin receptor 1B / HTR1B antibody - ARG63992 from Arigo Biolaboratories Category ELISA Kit

5-hydroxytryptamine receptor 1B, ELISA Kit - MBS285010 from MyBioSource Category ELISA Kit Prices $465.00, $790.00, $3,500.00, $6,655.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

5-hydroxytryptamine receptor 1B, ELISA Kit - MBS283748 from MyBioSource Category ELISA Kit Prices $465.00, $790.00, $3,500.00, $6,655.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

5-hydroxytryptamine receptor 1B, ELISA Kit - MBS284332 from MyBioSource Category ELISA Kit Prices $465.00, $790.00, $3,500.00, $6,655.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

5-hydroxytryptamine receptor 1B, ELISA Kit - MBS763414 from MyBioSource Category ELISA Kit Prices $295.00, $390.00, $1,615.00, $3,015.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 46.9pg/ml Range 78-5000pg/ml

5-hydroxytryptamine receptor 1B, ELISA Kit - MBS2880641 from MyBioSource Category ELISA Kit Prices $430.00, $570.00, $2,515.00, $4,520.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Range 78-5000 pg/mL

5-hydroxytryptamine receptor 1B, ELISA Kit - MBS9426421 from MyBioSource Category ELISA Kit Prices $670.00 Sizes 96 tests Sensitivity Less than 34pg/mL Range 78-5000 pg/mL

Human HTR1B / 5-HT1B Receptor ELISA Kit (Sandwich ELISA) - LS-F32596 from LifeSpan Bioscience Category ELISA Kit Sensitivity 46.9 Range 78-5000 pg/ml

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