HTR1B

Gene Symbol HTR1B
Entrez Gene 3351
Alt Symbol 5-HT1B, 5-HT1DB, HTR1D2, HTR1DB, S12
Species Human
Gene Type protein-coding
Description 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
Other Description 5-HT-1B|5-HT-1D-beta|5-hydroxytryptamine receptor 1B|serotonin 1D beta receptor|serotonin receptor 1B
Swissprots Q4VAY7 P28222
Accessions AAA36029 AAA36030 AAA58675 AAO67712 BAA01763 BAA94455 EAW48722 P28222 AK290080 BAF82769 AK315325 BAG37726 BC069065 AAH69065 BC096206 AAH96206 BC096207 AAH96207 BC096208 AAH96208 KJ534870 AHW56510 M81590 AAA60316 NM_000863 NP_000854
Function G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries. {ECO:0000269|PubMed:10452531, ECO:0000269|PubMed:1315531, ECO:0000269|PubMed:1328844, ECO:0000269|PubMed:1348246, ECO:0000269|PubMed:1351684, E
Subcellular Location Cell membrane {ECO:0000269|PubMed:10452531, ECO:0000269|PubMed:1315531, ECO:0000269|PubMed:1328844, ECO:0000269|PubMed:1348246, ECO:0000269|PubMed:1351684, ECO:0000269|PubMed:1559993, ECO:0000269|PubMed:1565658, ECO:0000269|PubMed:1610347, ECO:0000269|PubMed:23519210, ECO:0000269|PubMed:23519215}; Multi-pass membrane protein {ECO:0000269|PubMed:10452531, ECO:0000269|PubMed:1315531, ECO:0000269|PubMed:1328844, ECO:0000269|PubMed:1348246, ECO:0000269|PubMed:1351684, ECO:0000269|PubMed:1559993, ECO:0000269|PubMed:1565658, ECO:0000269|PubMed:1610347, ECO:0000269|PubMed:23519210, ECO:0000269|PubMed:23519215}.
Tissue Specificity Detected in cerebral artery smooth muscle cells (at protein level). Detected in brain cortex, striatum, amygdala, medulla, hippocampus, caudate nucleus and putamen. {ECO:0000269|PubMed:1348246, ECO:0000269|PubMed:1351684, ECO:0000269|PubMed:15853772}.
Top Pathways cAMP signaling pathway, Neuroactive ligand-receptor interaction

Human 5HT1B Receptor peptide - ab94829 from Abcam

Category Peptide
Prices $176.00
Sizes 100 µg

Human 5HT1B Receptor protein fragment - ab158711 from Abcam

Category Protein
Prices $402.00
Sizes 10 µg
Source Wheat germ
Species Human
ab158711 on a 12.5% SDS-PAGE stained with Coomassie Blue.

HTR1B / 5-HT1B Receptor Antibody Blocking Peptide - LS-E3399 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

HTR1B / 5-HT1B Receptor Antibody Blocking Peptide - LS-E29104 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 50 µg

HTR1B / 5-HT1B Receptor Antibody Blocking Peptide - LS-E29109 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 50 µg

HTR1B / 5-HT1B Receptor Antibody Blocking Peptide - LS-E26102 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

Recombinant Human 5-HT1B Protein - H00003351-Q01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

HTR1B-Antibody-Center-Blocking-Peptide - BP14575c from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

5-HT1B receptor blocking peptide - GTX89298-PEP from GeneTex

Category Peptide
Prices $239.00
Sizes 100 μg
Species Human, Mouse, Dog, Rat

HTR1B Blocking Peptide - 33R-5909 from Fitzgerald

Category Peptide
Prices $130.00
Sizes 100 µg

5HT1B Peptide - AC21-0930-P from Abcore

Category Peptide
Prices $160.00
Sizes 100 µg

Serotonin receptor 1B (HTR1B) - H00003351-Q01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

Serotonin receptor 1B (HTR1B) - H00003351-Q01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

Serotonin receptor 1B Peptide - 46-355P from ProSci

Category Peptide
Species Human

HTR1B fusion protein - Ag16753 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PET28a
Species Human

HTR1B fusion protein - ag16369 from Proteintech Group

Category Protein
Source E. coli-derived, PGEX-4T
Species Human

Recombinant Human HTR1B, His-tagged - HTR1B-14002H from Creative Biomart

Category Protein
Source E.coli
Species Human

SR-1B (M305) Peptide - BS2765P from Bioworld Technology

Category Peptide
Prices $158.00
Sizes 100 µl

5-hydroxytryptamine receptor 1B (HTR1B), Recombinant Protein - MBS1135376 from MyBioSource

Category Protein
Prices $1,810.00, $2,270.00
Sizes 1 mg (E-Coli), 1 mg (Yeast)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Chimpanzee

5-hydroxytryptamine receptor 1B (HTR1B), Recombinant Protein - MBS1115714 from MyBioSource

Category Protein
Prices $1,805.00, $2,265.00
Sizes 1 mg (E-Coli), 1 mg (Yeast)
Source E Coli or Yeast or Baculovirus or Mammalian Cell

5-hydroxytryptamine receptor 1B (HTR1B), Recombinant Protein - MBS965541 from MyBioSource

Category Protein
Prices $1,055.00, $1,835.00
Sizes 1 mg (E-Coli), 1 mg (Yeast)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human

Serotonin receptor 1B/HTR1B, Peptide - MBS426066 from MyBioSource

Category Peptide
Prices $175.00
Sizes 100 µg
Species Human, Mouse, Rat, Cat, Dog, Pig, Bovine

ChemiSCREEN™ Membrane Preparation Recombinant Human 5-HT 1B Serotonin Receptor - HTS108M from EMD Millipore

Prices $596.00
Sizes 200 units
Species Human

HTR1B Peptide, Human - M34GP07338H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

5-hydroxytryptamine receptor 1B, Recombinant Protein - MBS7042867 from MyBioSource

Category Protein
Prices $1,195.00, $2,180.00, $3,390.00
Sizes 10 µg, 50 µg, 100 µg
Source Cell Free Expression
Species Human
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