HTR1B

Gene Symbol HTR1B
Entrez Gene 3351
Alt Symbol 5-HT1B, 5-HT1DB, HTR1D2, HTR1DB, S12
Species Human
Gene Type protein-coding
Description 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
Other Description 5-HT-1B|5-HT-1D-beta|5-hydroxytryptamine receptor 1B|serotonin 1D beta receptor|serotonin receptor 1B
Swissprots Q4VAY7 P28222
Accessions AAA36029 AAA36030 AAA58675 AAO67712 BAA01763 BAA94455 EAW48722 P28222 AK290080 BAF82769 AK315325 BAG37726 BC069065 AAH69065 BC096206 AAH96206 BC096207 AAH96207 BC096208 AAH96208 KJ534870 AHW56510 M81590 AAA60316 NM_000863 NP_000854
Function G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries. {ECO:0000269|PubMed:10452531, ECO:0000269|PubMed:1315531, ECO:0000269|PubMed:1328844, ECO:0000269|PubMed:1348246, ECO:0000269|PubMed:1351684, E
Subcellular Location Cell membrane {ECO:0000269|PubMed:10452531, ECO:0000269|PubMed:1315531, ECO:0000269|PubMed:1328844, ECO:0000269|PubMed:1348246, ECO:0000269|PubMed:1351684, ECO:0000269|PubMed:1559993, ECO:0000269|PubMed:1565658, ECO:0000269|PubMed:1610347, ECO:0000269|PubMed:23519210, ECO:0000269|PubMed:23519215}; Multi-pass membrane protein {ECO:0000269|PubMed:10452531, ECO:0000269|PubMed:1315531, ECO:0000269|PubMed:1328844, ECO:0000269|PubMed:1348246, ECO:0000269|PubMed:1351684, ECO:0000269|PubMed:1559993, ECO:0000269|PubMed:1565658, ECO:0000269|PubMed:1610347, ECO:0000269|PubMed:23519210, ECO:0000269|PubMed:23519215}.
Tissue Specificity Detected in cerebral artery smooth muscle cells (at protein level). Detected in brain cortex, striatum, amygdala, medulla, hippocampus, caudate nucleus and putamen. {ECO:0000269|PubMed:1348246, ECO:0000269|PubMed:1351684, ECO:0000269|PubMed:15853772}.
Top Pathways cAMP signaling pathway, Neuroactive ligand-receptor interaction

HTR1B 293 Cell Lysate - 410117 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

5-HT1B Overexpression Lysate (Native) - NBL1-11775 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: 5HT1B Receptor Overexpression Lysate (Adult Normal) [NBL1-11775] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for 5HT1B Receptor.

HTR1B Over-expression Lysate Product - GWB-3E750B from Genway Biotech

Category Cell Lysate
Prices $445.00
Sizes 100 µg
Species Human

Panoply™ Human HTR1B Knockdown Stable Cell Line - CSC-DC007338 from Creative biogene

Category Cell Line
Species Human
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