HTR1B

Gene Symbol HTR1B
Entrez Gene 3351
Alt Symbol 5-HT1B, 5-HT1DB, HTR1D2, HTR1DB, S12
Species Human
Gene Type protein-coding
Description 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
Other Description 5-HT-1B|5-HT-1D-beta|5-hydroxytryptamine receptor 1B|serotonin 1D beta receptor|serotonin receptor 1B
Swissprots Q4VAY7 P28222
Accessions AAA36029 AAA36030 AAA58675 AAO67712 BAA01763 BAA94455 EAW48722 P28222 AK290080 BAF82769 AK315325 BAG37726 BC069065 AAH69065 BC096206 AAH96206 BC096207 AAH96207 BC096208 AAH96208 KJ534870 AHW56510 M81590 AAA60316 NM_000863 NP_000854
Function G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries. {ECO:0000269|PubMed:10452531, ECO:0000269|PubMed:1315531, ECO:0000269|PubMed:1328844, ECO:0000269|PubMed:1348246, ECO:0000269|PubMed:1351684, E
Subcellular Location Cell membrane {ECO:0000269|PubMed:10452531, ECO:0000269|PubMed:1315531, ECO:0000269|PubMed:1328844, ECO:0000269|PubMed:1348246, ECO:0000269|PubMed:1351684, ECO:0000269|PubMed:1559993, ECO:0000269|PubMed:1565658, ECO:0000269|PubMed:1610347, ECO:0000269|PubMed:23519210, ECO:0000269|PubMed:23519215}; Multi-pass membrane protein {ECO:0000269|PubMed:10452531, ECO:0000269|PubMed:1315531, ECO:0000269|PubMed:1328844, ECO:0000269|PubMed:1348246, ECO:0000269|PubMed:1351684, ECO:0000269|PubMed:1559993, ECO:0000269|PubMed:1565658, ECO:0000269|PubMed:1610347, ECO:0000269|PubMed:23519210, ECO:0000269|PubMed:23519215}.
Tissue Specificity Detected in cerebral artery smooth muscle cells (at protein level). Detected in brain cortex, striatum, amygdala, medulla, hippocampus, caudate nucleus and putamen. {ECO:0000269|PubMed:1348246, ECO:0000269|PubMed:1351684, ECO:0000269|PubMed:15853772}.
Top Pathways cAMP signaling pathway, Neuroactive ligand-receptor interaction

SR-1B (C-19)-R - sc-1460-R from Santa Cruz Biotechnology

Prices $61.00
Sizes 100 µg/0.5 ml
Host Rabbit
Clonality Polyclonal
SR-1B (C-19): sc-1460. Western blot analysis of serotonin 1B receptor expression in rat brain extract.

SR-1B (H-44) - sc-28937 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

SR-1B (L-14) - sc-32545 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-5HT1B Receptor antibody - ab102700 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-5HT1B Receptor antibody - ab85937 from Abcam

Prices $388.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
5HT1B Receptor antibody at 1 µg/ml + Brain (Human) Tissue Lysate - adult normal tissue (ab29466) at 10 µgSecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-5HT1B Receptor antibody - ab123372 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-5HT1B Receptor antibody (ab123372)SecondaryHL-60 cell lysate at 35 µg

Anti-5HT1B Receptor antibody - ab13896 from Abcam

Prices $390.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab17976 staining 5HT1B in Human colon tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with 10% NBFand blocked with antibody block for 10 minutes; antigen retrieval was by heat mediation in CC1 Mild. Samples were incubated with primary antibody (1/100 in antibody diluent) for 1 hour at 37°C. An undiluted Biotin-conjugated Goat anti-rabbit IgG polyclonal was used as the secondary antibody.See Abreview

Anti-HTR1B / 5-HT1B Receptor Antibody (aa224-253, Azide-free, HRP) - LS-C222772 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HTR1B / 5-HT1B Receptor Antibody (Cytoplasmic Domain) IHC-plus™ - LS-A598 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-5HT1B Receptor antibody LS-A598 IHC of human vascular smooth muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-HTR1B / 5-HT1B Receptor Antibody (aa201-250) - LS-C291270 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HTR1B / 5-HT1B Receptor Antibody (aa179-228) - LS-C200060 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of the lysates from HepG2 cells using 5-HT-1B antibody.

Anti-HTR1B / 5-HT1B Receptor Antibody (aa224-253) - LS-C329646 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HTR1B / 5-HT1B Receptor Antibody (aa224-253, PE) - LS-C222774 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HTR1B / 5-HT1B Receptor Antibody (aa256-305) - LS-C292087 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HTR1B / 5-HT1B Receptor Antibody (aa225-253) - LS-C165080 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
HTR1B Antibody western blot of HL-60 cell line lysates (35 ug/lane). The HTR1B antibody detected the HTR1B protein (arrow).

Anti-HTR1B / 5-HT1B Receptor Antibody (Met305) - LS-C177177 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of SR-1B (M305) pAb in extracts from K562 cells.

Anti-HTR1B / 5-HT1B Receptor Antibody (Internal) IHC-plus™ - LS-A586 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-5HT1B Receptor antibody LS-A586 IHC of human vessel. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-HTR1B / 5-HT1B Receptor Antibody (aa8-26) - LS-C611 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of 5-HT1BR in human brain lysate with anti-5-HT1BR pcAb. A protein band of approximate molecular weight of 40-41kD was detected.

Anti-HTR1B / 5-HT1B Receptor Antibody (aa8-26) - LS-C91321 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HTR1B / 5-HT1B Receptor Antibody - LS-C124520 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-HTR1B / 5-HT1B Receptor Antibody (N-Terminus) - LS-C30931 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
HepG2 Cell Lysate

Anti-HTR1B / 5-HT1B Receptor Antibody (aa224-253, AP) - LS-C222767 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HTR1B / 5-HT1B Receptor Antibody (aa224-253, APC) - LS-C222769 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HTR1B / 5-HT1B Receptor Antibody (aa261-310) - LS-C120543 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of A549 cells, using HTR1B Antibody. The picture on the right is treated with the synthesized peptide.

Anti-HTR1B / 5-HT1B Receptor Antibody (aa224-253, Biotin) - LS-C222770 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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