| Gene Symbol |
USP22
|
| Entrez Gene |
23326
|
| Alt Symbol |
USP3L
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin specific peptidase 22
|
| Other Description |
deubiquitinating enzyme 22|ubiquitin carboxyl-terminal hydrolase 22|ubiquitin specific protease 22|ubiquitin thioesterase 22|ubiquitin thiolesterase 22|ubiquitin-specific processing protease 22|ubiquitin-specific-processing protease 22
|
| Swissprots |
A0JNS3 Q9UPT9 Q8TBS8 Q6MZY4 Q96IW5 Q2NLE2
|
| Accessions |
Q9UPT9 AB028986 BAA83015 AK025331 AK130677 AL049258 AL110213 BC007196 AAH07196 BC013364 BC025317 AAH25317 BC050994 BC084550 BC110499 AAI10500 BC126898 AAI26899 BX640815 CAE45893 DQ581604 XM_005256575 XP_005256632 NM_015276 NP_056091
|
| Function |
Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression. {ECO:0000269|PubMed:18206972, ECO:0000269|PubMed:18206973, ECO:0000269|PubMed:18469533}.
|
| Subcellular Location |
Nucleus {ECO:0000305}.
|
| Tissue Specificity |
Moderately expressed in various tissues including heart and skeletal muscle, and weakly expressed in lung and liver. {ECO:0000269|PubMed:16378762}.
|
![Western Blot: USP22 Overexpression Lysate (Adult Normal) [NBL1-17653] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for USP22.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9812_USP22%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-17653-img0002.jpg)