Gene Symbol | USP22 |
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Entrez Gene | 23326 |
Alt Symbol | USP3L |
Species | Human |
Gene Type | protein-coding |
Description | ubiquitin specific peptidase 22 |
Other Description | deubiquitinating enzyme 22|ubiquitin carboxyl-terminal hydrolase 22|ubiquitin specific protease 22|ubiquitin thioesterase 22|ubiquitin thiolesterase 22|ubiquitin-specific processing protease 22|ubiquitin-specific-processing protease 22 |
Swissprots | A0JNS3 Q9UPT9 Q8TBS8 Q6MZY4 Q96IW5 Q2NLE2 |
Accessions | Q9UPT9 AB028986 BAA83015 AK025331 AK130677 AL049258 AL110213 BC007196 AAH07196 BC013364 BC025317 AAH25317 BC050994 BC084550 BC110499 AAI10500 BC126898 AAI26899 BX640815 CAE45893 DQ581604 XM_005256575 XP_005256632 NM_015276 NP_056091 |
Function | Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression. {ECO:0000269|PubMed:18206972, ECO:0000269|PubMed:18206973, ECO:0000269|PubMed:18469533}. |
Subcellular Location | Nucleus {ECO:0000305}. |
Tissue Specificity | Moderately expressed in various tissues including heart and skeletal muscle, and weakly expressed in lung and liver. {ECO:0000269|PubMed:16378762}. |
USP22 CRISPR/Cas9 KO Plasmid (h) - sc-403660 from Santa Cruz Biotechnology
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USP22 HDR Plasmid (h) - sc-403660-HDR from Santa Cruz Biotechnology
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USP22 Double Nickase Plasmid (h) - sc-403660-NIC from Santa Cruz Biotechnology
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USP22 Double Nickase Plasmid (h2) - sc-403660-NIC-2 from Santa Cruz Biotechnology
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USP22 CRISPR Activation Plasmid (h) - sc-403660-ACT from Santa Cruz Biotechnology
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USP22 CRISPR Activation Plasmid (h2) - sc-403660-ACT-2 from Santa Cruz Biotechnology
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USP22 Lentiviral Activation Particles (h) - sc-403660-LAC from Santa Cruz Biotechnology
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USP22 Lentiviral Activation Particles (h2) - sc-403660-LAC-2 from Santa Cruz Biotechnology
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USP22 siRNA (h) - sc-63195 from Santa Cruz Biotechnology
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USP22 shRNA Plasmid (h) - sc-63195-SH from Santa Cruz Biotechnology
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USP22 shRNA (h) Lentiviral Particles - sc-63195-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU120531 from Sigma-Aldrich
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MISSION® esiRNA - EHU013941 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22571 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22571 from Sigma-Aldrich
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USP22 siRNA (Human) - CRH8182 from Cohesion Biosciences
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USP22 - MBS8235287 from MyBioSource
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shRNA set against Human USP22 (NM_015276.1) - SHH441372 from Creative biogene
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Human USP22 siRNA - orb268684 from Biorbyt
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USP22 shRNA Plasmid (Human) - CHH8182 from Cohesion Biosciences
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