| Gene Symbol |
FICD
|
| Entrez Gene |
11153
|
| Alt Symbol |
HIP13, HYPE, UNQ3041
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
FIC domain containing
|
| Other Description |
AMPylator FICD|FIC domain-containing protein|HIP-13|Huntingtin interacting protein E|adenosine monophosphate-protein transferase FICD|fic S-phase protein cell division homolog|huntingtin interacting protein 13|huntingtin interactor protein E|huntingtin yeast partner E|huntingtin-interacting protein 13|huntingtin-interacting protein E
|
| Swissprots |
Q9BVA6 O75406
|
| Accessions |
EAW97813 EAW97814 EAW97815 Q9BVA6 AF049611 AAC26847 AK000014 AK026074 AY358992 AAQ89351 BC001342 AAH01342 BC064629 DQ891787 ABM82713 EU176625 ABW03426 XM_011537793 XP_011536095 NM_007076 NP_009007
|
| Function |
Adenylyltransferase that mediates the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins. Able to inactivate Rho GTPases in vitro by adding AMP to RhoA, Rac and Cdc42. It is however unclear whether it inactivates GTPases in vivo and physiological substrates probably remain to be identified. {ECO:0000269|PubMed:19362538, ECO:0000269|PubMed:22266942}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Ubiquitous. {ECO:0000269|PubMed:19362538}.
|
![Western Blot: HYPE Overexpression Lysate (Adult Normal) [NBL1-10720] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for HYPE.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3287_HYPE%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-10720-img0002.jpg)