Angptl4

Gene Symbol	Angptl4
Entrez Gene	57875
Alt Symbol	Arp4, Bk89, Fiaf, Hfarp, Ng27, Pgar, Pgarg, Pp1158
Species	Mouse
Gene Type	protein-coding
Description	angiopoietin-like 4
Other Description	425O18-1|angiopoietin-like protein 4|angiopoietin-related protein 4|fasting-induced adipose factor|fibrinogen/angiopoietin-related protein|hepatic fibrinogen/angiopoietin-related protein|major histocompatibility complex region NG27|secreted protein Bk89
Swissprots	Q9JHX7 Q9JLX7 Q78ZJ9 Q9Z1P8
Accessions	AAC97965 AAO17378 EDL10208 Q9Z1P8 AB054540 BAB83079 AF123261 AAF42969 AF169313 AAF62869 AF278699 AAF86342 AK009161 BAC25242 AK014564 BAB29431 AK032491 AK132761 BAE21342 AK134419 BAE22137 AW495750 BC006611 AAH06611 BC021343 AAH21343 BC025797 AAH25797 BY783212 KJ650202 AIC83990 NM_020581 NP_065606
Function	Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity (By similarity). In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation. {ECO:0000250, ECO:0000269|PubMed:15837923, ECO:0000269|PubMed:17068295, ECO:0000269|PubMed:17130448}.
Subcellular Location	Secreted {ECO:0000269|PubMed:17068295}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:17068295}. Note=The unprocessed form interacts with the extracellular matrix. This may constitute a dynamic reservoir, a regulatory mechanism of the bioavailability of ANGPTL4.
Tissue Specificity	Predominantly expressed in adipose tissue and is strongly up-regulated by fasting in white adipose tissue and liver. {ECO:0000269|PubMed:10862772}.
Top Pathways	PPAR signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Angiopoietin-related protein 4, Angptl4, Mouse, ELISA Kit - E2085m from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 78-5000 pg/mL

Mouse ANGPTL4 ELISA Kit - MA0514 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Mouse ANGPTL4(Angiopoietin Like Protein 4) ELISA Kit - E-EL-M0093 from Elabscience Category ELISA Kit Sensitivity 0.10 ng/mL Range 0.16—10 ng/mL

Mouse ANGPTL4 (Angiopoietin Like Protein 4) CLIA Kit - E-CL-M0080 from Elabscience Category CLIA Kit Sensitivity 18.75 pg/mL Range Average Recovery (%)

angiopoietin-like 4, ELISA Kit - MBS915491 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.781 pg/ml. Range 3.125 pg/ml-200 pg/ml.

Mouse Angiopoietin-related protein 4(ANGPTL4) ELISA kit - CSB-EL001712MO from Cusabio Category ELISA Kit Sensitivity 0.78 pg/ml Range 3.12 pg/ml-200 pg/ml

Mouse Angiopoietin Like Protein 4 ELISA - E03A0507 from BlueGene Biotech Category ELISA Kit Sensitivity 1.0pg/mL

Mouse ANGPTL4 (Angiopoietin Like Protein 4) CLIA Kit - E-CL-M0080 from Iwai North America Inc. Category CLIA Kit Prices $722.50 Sizes 1 kit Sensitivity 0.094ng/mL Range 0.156-10ng/mL

Mouse ANGPTL4 ELISA Kit - abx153641 from Abbexa Category ELISA Kit Range 0.781 ng/ml - 50 ng/ml

Angiopoietin Like Protein 4 (ANGPTL4), Mouse, ELISA Kit - DL-ANGPTL4-Mu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Range 0.156-10 ng/mL

Mouse ANGPTL4 ELISA Kit - abx570701 from Abbexa Category ELISA Kit Sensitivity 0.065 ng/ml Range 0.156 ng/ml - 10 ng/ml

ANGPTL4 - EKM1442 from Nordic BioSite Sensitivity 0.094ng/ml Range 0.156-10ng/ml

Mouse Angptl4 ELISA Kit - E043801 from Biobool Category ELISA Kit Sensitivity <0.094ng/ml

Mouse ANGPTL-4 ELISA Kit - E043905 from Biobool Category ELISA Kit Sensitivity 0.094ng/mL

ANGPTL4 ELISA Kit (Mouse) (OKEH03450) - OKEH03450 from Aviva Systems Biology Category ELISA Kit Prices $425.00 Sizes 96 wells Sensitivity <78 pg/mL Range 0.156-10 ng/mL

Mouse ANGPTL4 ELISA Kit - EMA0514 from ABclonal Category ELISA Kit Prices $495.00 Sizes 96 t

Mouse Angiopoietin-related protein 4 ELISA Kit - EK4265 from Signalway Antibody Category ELISA Kit Prices $599.00 Sizes 1x96t Range 0.312-20 ng/ml

Angiopoietin Like Protein 4 (ANGPTL4), ELISA Kit - MBS452586 from MyBioSource Category ELISA Kit Prices $410.00, $540.00, $2,380.00, $4,620.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity <0.065ng/mL Range 0.156-10ng/mL

Angiopoietin-related protein 4, ELISA Kit - MBS9428091 from MyBioSource Category ELISA Kit Prices $555.00 Sizes 96 tests Range 78-5000 pg/mL

Angiopoietin-related protein 4, ELISA Kit - MBS2885878 from MyBioSource Category ELISA Kit Prices $380.00, $500.00, $2,170.00, $3,840.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mouse ANGPTL4 ELISA Kit - orb409463 from Biorbyt Category ELISA Kit Sensitivity 0.78 pg/ml Range 3.12 pg/ml-200 pg/ml

Mouse ANGPTL4 (Angiopoietin Like Protein 4) ELISA Kit - EKE61515 from Biomatik Category ELISA Kit Prices $609.00 Sizes 96 tests Sensitivity 0.1 ng/mL Range 0.16-10 ng/mL

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