Angptl4

Gene Symbol	Angptl4
Entrez Gene	57875
Alt Symbol	Arp4, Bk89, Fiaf, Hfarp, Ng27, Pgar, Pgarg, Pp1158
Species	Mouse
Gene Type	protein-coding
Description	angiopoietin-like 4
Other Description	425O18-1|angiopoietin-like protein 4|angiopoietin-related protein 4|fasting-induced adipose factor|fibrinogen/angiopoietin-related protein|hepatic fibrinogen/angiopoietin-related protein|major histocompatibility complex region NG27|secreted protein Bk89
Swissprots	Q9JHX7 Q9JLX7 Q78ZJ9 Q9Z1P8
Accessions	AAC97965 AAO17378 EDL10208 Q9Z1P8 AB054540 BAB83079 AF123261 AAF42969 AF169313 AAF62869 AF278699 AAF86342 AK009161 BAC25242 AK014564 BAB29431 AK032491 AK132761 BAE21342 AK134419 BAE22137 AW495750 BC006611 AAH06611 BC021343 AAH21343 BC025797 AAH25797 BY783212 KJ650202 AIC83990 NM_020581 NP_065606
Function	Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity (By similarity). In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation. {ECO:0000250, ECO:0000269|PubMed:15837923, ECO:0000269|PubMed:17068295, ECO:0000269|PubMed:17130448}.
Subcellular Location	Secreted {ECO:0000269|PubMed:17068295}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:17068295}. Note=The unprocessed form interacts with the extracellular matrix. This may constitute a dynamic reservoir, a regulatory mechanism of the bioavailability of ANGPTL4.
Tissue Specificity	Predominantly expressed in adipose tissue and is strongly up-regulated by fasting in white adipose tissue and liver. {ECO:0000269|PubMed:10862772}.
Top Pathways	PPAR signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Angiopoietin-like 4 (mouse) blocking peptide - GTX88798-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Mouse, Rat

Recombinant Mouse Angiopoietin-like 4, CF - 4880-AN-050 from R&D Systems Category Protein Source Chinese Hamster Ovary cell line, CHO-derived, Gln24-Ser410, with a C-terminal 6-His tag

Mouse Angiopoietin like 4 protein - orb138184 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Cells Species Mouse

Mouse ANGPTL4 Protein - abx065337 from Abbexa Category Protein Source E.coli Species Mouse

ANGPTL4 / FIAF Control Peptide - AP00211CP-N from Acris Antibodies Category Peptide Prices $205.00 Sizes 50 µg

ANGPTL4 / FIAF control peptide - SP5166CP from Acris Antibodies Category Peptide Prices $205.00 Sizes 50 µg

Angiopoietin Like Protein 4 (ANGPTL4), Mouse - 20-7399 from ARP American Research Products Category Protein Prices $449.00 Sizes 50 µg Source E.coli Species Mouse

Recombinant Mouse Angptl4, FLAG-tagged - Angptl4-105M from Creative Biomart Category Protein Source COS-7 cells Species Mouse

Recombinant Mouse Angptl4, His-tagged - Angptl4-476M from Creative Biomart Category Protein Source Human Cells Species Mouse

Recombinant Mouse Angptl4, FLAG-tagged - Angptl4-101M from Creative Biomart Category Protein Source HEK293 Cells Species Mouse

Recombinant Mouse Angptl4, His-tagged - Angptl4-406M from Creative Biomart Category Protein Source E. coli

Recombinant Mouse Angptl4, Flag-tagged - Angptl4-407M from Creative Biomart Category Protein Source HEK 293 cells

Recombinant Mouse Angiopoietin-like 4, FLAG-tagged - Angptl4-405M from Creative Biomart Category Protein Source COS-7 cells .

Recombinant Mouse Angiopoietin-like 4, Coiled-Coil Domain, His-tagged - ANGPTL4-402M from Creative Biomart Category Protein Source HEK 293.

Mouse ANGPTL4 Protein (His Tag) - 50356-M07H-50 from Sino Biological Category Protein Source Human Cells Species Mouse

ANGPTL4 - ABP-309-031000 from Nordic BioSite Category Protein Species Mouse

ANGPTL4 - ABP-309-03100 from Nordic BioSite Category Protein Species Mouse

ANGPTL4 - ABP-309-0310 from Nordic BioSite Category Protein Species Mouse

ANGPTL4 - ABP-309-0320 from Nordic BioSite Category Protein Species Mouse

ANGPTL4 - ABP-309-0350 from Nordic BioSite Category Protein Species Mouse

Recombinant Mouse Angiopoietin-like 4 Protein, CF - 4880-AN from R&D Systems Category Protein Prices $359.00 Sizes 50 µg Source Chinese Hamster Ovary cell line, CHO-derived Gln24-Ser410, with a C-terminal 6-His tag Species Mouse

Angiopoietin Like Protein 4 (ANGPTL4), Recombinant Protein - MBS2011150 from MyBioSource Category Protein Prices $220.00, $385.00, $560.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Mouse

FIAF, Peptide - MBS843916 from MyBioSource Category Peptide Prices $165.00 Sizes 50 µg

Mouse ANGPTL4 protein (C-Fc) - orb311653 from Biorbyt Category Protein Prices $264.00, $451.00, $2,032.00, $2,882.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Mouse

ANGPTL4 Recombinant Protein (OPCD01325) - OPCD01325 from Aviva Systems Biology Category Protein Source E.coli Species Mouse

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