Angptl4

Gene Symbol Angptl4
Entrez Gene 57875
Alt Symbol Arp4, Bk89, Fiaf, Hfarp, Ng27, Pgar, Pgarg, Pp1158
Species Mouse
Gene Type protein-coding
Description angiopoietin-like 4
Other Description 425O18-1|angiopoietin-like protein 4|angiopoietin-related protein 4|fasting-induced adipose factor|fibrinogen/angiopoietin-related protein|hepatic fibrinogen/angiopoietin-related protein|major histocompatibility complex region NG27|secreted protein Bk89
Swissprots Q9JHX7 Q9JLX7 Q78ZJ9 Q9Z1P8
Accessions AAC97965 AAO17378 EDL10208 Q9Z1P8 AB054540 BAB83079 AF123261 AAF42969 AF169313 AAF62869 AF278699 AAF86342 AK009161 BAC25242 AK014564 BAB29431 AK032491 AK132761 BAE21342 AK134419 BAE22137 AW495750 BC006611 AAH06611 BC021343 AAH21343 BC025797 AAH25797 BY783212 KJ650202 AIC83990 NM_020581 NP_065606
Function Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity (By similarity). In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation. {ECO:0000250, ECO:0000269|PubMed:15837923, ECO:0000269|PubMed:17068295, ECO:0000269|PubMed:17130448}.
Subcellular Location Secreted {ECO:0000269|PubMed:17068295}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:17068295}. Note=The unprocessed form interacts with the extracellular matrix. This may constitute a dynamic reservoir, a regulatory mechanism of the bioavailability of ANGPTL4.
Tissue Specificity Predominantly expressed in adipose tissue and is strongly up-regulated by fasting in white adipose tissue and liver. {ECO:0000269|PubMed:10862772}.
Top Pathways PPAR signaling pathway

Angptl4 CRISPR/Cas9 KO Plasmid (m) - sc-425454 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Angptl4 HDR Plasmid (m) - sc-425454-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Angptl4 Double Nickase Plasmid (m) - sc-425454-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Angptl4 Double Nickase Plasmid (m2) - sc-425454-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Angptl4 CRISPR Activation Plasmid (m) - sc-425454-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Angptl4 CRISPR Activation Plasmid (m2) - sc-425454-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Angptl4 Lentiviral Activation Particles (m) - sc-425454-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Angptl4 Lentiviral Activation Particles (m2) - sc-425454-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

Angptl4 siRNA (m) - sc-44665 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

Angptl4 shRNA Plasmid (m) - sc-44665-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

Angptl4 shRNA (m) Lentiviral Particles - sc-44665-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

MISSION® esiRNA - EMU001991 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN26671 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND26671 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

ANGPTL4 siRNA (Mouse) - CRM6070 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

ANGPTL4 - MBS827169 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

shRNA set against Mouse ANGPTL4 (NM_020581.2) - SHH236298 from Creative biogene

Category siRNA
Species Reactivities Mouse

Mouse ANGPTL4 siRNA - orb285546 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

ANGPTL4 shRNA Plasmid (Mouse) - CHM6070 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Mouse
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